Sheldon: That show ended with all the residents of New York either dead or unconscious. Oh, now I'll never know what happened.
Penny: Well, why don't you make up your own ending?
Sheldon: Oh, sure, what a wonderful idea. And after that, I'll make up my own rules of oral hygiene. You know, instead of flossing, I'll rub pudding on my gums.

Sheldon: Hello, SyFy Network? Yeah, this is your vice president of programming. Now, we have made a horrible mistake regarding Alphas. Yeah, we need to uncancel it immediately. Well, you just put me through to the people who handle that, you tell them it's me, and I don't want to answer a lot of questions about if I really am who I say I am, you know? I just, I want this done. No, I am not the person who just called. That man was clearly a cowboy. Yeah, who was plumb concerned about yall canceling his favorite show. Why do they keep hanging up on me?

Amy: I'm sorry you're upset. You know, Sheldon, sometimes people seek the comfort of physical contact in moments like this.
Sheldon: I am not flying back to Texas just so my mom can give me a hug.

Sheldon: Tic-tac-toe can only end in win, lose or draw, none of which will deny me closure. Especially since I'm about to win. (Amy wipes the board clean.) But we didn't finish.
Amy: Exactly. How does that make you feel?
Sheldon: The same way any normal person would. I feel like I want to peel off my own face and tear it in two and then again and again until I have a handful of Sheldon-face confetti.
Amy: And thats exactly the feeling we want to address with this course of treatment.
Sheldon: Or you could pitch in, grab a nostril and help me get this face off.

Sheldon: It is glorious. One of the greatest intellects of our time has agreed to engage with me in a gentlemanly battle of wits. And I'm spanking him so hard his grad students won't be able to sit down.

Leonard: Uh, that's my water.
Sheldon: What?
Leonard: My water. You're drinking it.
Sheldon: Dear Lord! Have you been drinking it?
Leonard: Yes. It's my water.
Sheldon: Well, that's it then. I'm dead.

Leonard: Here we go.
Sheldon: I'm sorry, do I really need to connect the dots for you? The backwash into this glass is every pathogen that calls your mouth home, sweet home. Not to mention the visitors who arrive on the dancing tongue of your subtropical girlfriend.

Bernadette: You guys ready to order?
Sheldon: Yes, Id like a seven-day course of penicillin, some, uh, syrup of ipecac to induce vomiting, and a mint.

Leonard: That's actually my napkin.
Sheldon: Oh, this is a nightmare!
Howard: Where are you going?
Sheldon: To the bar, to sterilize my mouth with alcohol. Gangway, dead man walking!

Leonard: Howard and his mother are at the hospital. Come on, we gotta go.
Penny: Oh, my God! What happened?
Leonard: I don't know, I just got a text. Come on, hurry.
Penny: Okay.
Leonard: Sheldon, let's go!
Sheldon: To a hospital? Full of sick people? Oh, I don't think so.
Penny: Okay, well, your friend and his mother are there, we're going.
Sheldon: I can't.
Penny: Oh, don't tell me you're afraid of germs.
Sheldon: Not all germs. Just the ones that will kill me. It's the same way I'm not afraid of all steak knives, just the ones that might be plunged in my thorax.
Leonard: Right, fine. I'll tell Howard you didn't come because you're more concerned about your own well-being than his.
Sheldon: I would think he would know that.

Penny: Okay, you know what? You are unbelievable. You buy all these superhero T-shirts, but when it's time for you to step up and do the right thing, you just hide in the laundry room.
Sheldon: Fine, I'll go. Just for the record, my Aunt Ruth died in a hospital. She went in to visit my Uncle Roger, caught something and bit the dust a week later. The two of them now share a coffee can on my mother's mantel.

Sheldon: Regardless, coronary problems are eminently treatable. What's more likely going to kill Howard's mother are the antibiotic-resistant super-bugs festering in every nook and cranny of this hospital.
Penny: Okay, you're not helping.
Sheldon: Disagree.

Sheldon: Oh, President Siebert, I assume you'd like to respond to one of the suggestions I put in the box by your office.
President Siebert: No, and stop installing suggestion boxes everywhere.
Sheldon: You don't like written suggestions. You don't like when I give them to you while we're urinating in the men's room. If I didn't know any better, I'd say that you're one of those stubborn people who are not open to suggestions.

Howard: How about Florida? They've got Cape Canaveral, they've got Disney, they've got my Aunt Ida and the world's largest collection of diabetic candy. Plus, if you get sweaty enough, her plastic-covered furniture is like a flume ride.
Sheldon: My family took a trip to Florida when I was a child. A seagull stole a hot dog from me on the beach. I got the message.

Leonard: Sheldon, everybody takes vacations.
Sheldon: One time they tried to make Richard Feynman take a vacation, but he chose instead to expand his mind and learn something new. He went to work in his friends biology lab. Richard Feynman was a famous American physicist, part of the Manhattan Project.
Howard: Everyone in the world of science knows who Richard Feynman was.
Sheldon: Now you do, too.