Sheldon: Oh! I have a brilliant idea. Amy's a biologist. I'll go work in her lab.
Howard: Isn't that just Feynmans idea?
Sheldon: Ten seconds ago, you never heard of him. Now you're an expert.

Sheldon: 366, 367
Amy: How's it going?
Sheldon: How's counting going? When I was in kindergarten, I recited Pi to a thousand places for the school talent show. I think I got this.
Amy: Great.
Sheldon: Aw, nuts! One

Sheldon: This is preposterous. I think you're giving me these tasks because you're afraid if you give me anything meaningful to do, I'll show you up.
Amy: Really? Is that what you think?
Sheldon: Yes, that's what I think. And I'm super smart, so it's probably true.

Amy: Hey, I've been training in the field of neurobiology for 12 years. You've been here for three hours, and you've spent one of them in the bathroom.
Sheldon: I'm sorry. It takes me a while to get things going on an unfamiliar toilet.

Amy: Sheldon, I've given you the simplest things to do, and you haven't done one of them right.
Sheldon: Maybe that's because I'm not being challenged. It's the same reason Einstein failed math.
Amy: Maybe the math was too bubbly for him.
Sheldon: You think you're doing science by cutting up that brain? They could do the same thing at any Quiznos. And they'd offer to toast it for me, too.

Amy: Okay, smart guy. I'm about to remove the locus coeruleus, which is incredibly delicate work. Have at it.
Sheldon: All right. I'm no stranger to a little gray matter. Locus coeruleus. Locus coeruleus.
Amy: You're getting warmer, it is, indeed, in the brain. Hope your hands are steady. It's the width of a single hair. But this is just biology, so I'm sure it's no problem for a genius like you.
Sheldon: It's not. I'll have you know, in the field of physics, we work with particles so small, they make fat jokes about the locus coeruleus, i.e., when your locus coeruleus sits around the house, it sits around the house.

Sheldon: Does a locus coeruleus normally bleed that much?
Amy: No. But your thumb does.
Sheldon: Oh, dear. (Faints)

Howard: What happened to your thumb?
Sheldon: You know, I have ten fingers and ten toes. If I tell you a story about each one of them, we'll be here all day, let's just move on.

Sheldon: Ah, seeing as I'm on vacation, a pina colada seems appropriate. Extra pineapple slices, extra whipped cream, extra cherries, extra umbrellas, and, uh, hold the rum. Don't let me have too many of those.

Sheldon: I was kind of hoping I could continue vacationing in your laboratory. After all, I did book the whole week.
Amy: Do you honestly think you can just waltz back in here after the way you behaved yesterday?
Sheldon: I was not myself. I had lost a lot of thumb blood.
Amy: That's not an apology.
Sheldon: That is your opinion.

Amy: Now, if you want to stay, get started on those beakers. They're still dirty from yesterday.
Sheldon: Next year I'm going to Epcot.

Amy: You know, ever since I was a young girl, I've dreamed of a June wedding, maybe on a cliff overlooking the ocean at sunset.
Sheldon: Sure. Sounds wonderful. Now, if you'll excuse me, I'm going to go clean up. (To himself) Outdoor wedding. I know what I'll be using that cliff for.

Leonard: Hey, Sheldon, clear your weekend. Starting Saturday morning, Star Wars marathon.
Raj: Woo-hoo!
Sheldon: Movies or video games? Or board game? Or trading card games? Or Lego's? Or dress up? Or comic books? Or dramatic readings of novelizations? Yes to all!
Leonard: We are going to play the online game.
Sheldon: The online game? Bully!

Sheldon: Amy, the relationship agreement was not designed for either one of us to get our way.
Amy: You use it to get your way.
Sheldon: I use it to get the right way. The fact that the right way is also my way is a happy coincidence.

Sheldon: What else?
Stuart: Hmm. Oh, have this collectors edition Batman utility belt. Maybe she can use it as a wearable pill caddy.
Sheldon: Well, she'd just look silly wearing that without the rest of the costume.