Sheldon: You know, in the future, when we're disembodied brains in jars, we're going to look back on this as eight hours well wasted.
Raj: I don't want to be in a jar. I want my brain in an android body. Eight feet tall and ripped.
Howard: I'm with you. I just have to make sure if I'm a synthetic human I'd still be Jewish. I promised my mother.
Raj: I suppose you could have your android penis circumcised. But that's something your Rabbi would have to discuss with the manufacturers.
Sheldon: Not to mention you'd have to power down on Saturdays.

Leonard: Okay, if I may drill down to the bedrock of my question, why did you throw it out?
Sheldon: Because I have no interest in standing in the Rose Room of the Pasadena Marriott in front of a group of judgmental strangers, who wouldn't recognize true genius if it were standing in front of them giving a speech. Which, if I were there, it would be.

Penny: He means he's writing a book.
Leonard: I do. It's something I've been thinking about for a long time. Yeah. It's about a brilliant physicist who solves crimes using science.
Sheldon: Oh, Leonard-
Leonard: It's not about you.
Sheldon: He probably has to say that for legal reasons.

Amy: Item 28 - Your Pet Name for me. Time is running out on this. You need to make a decision.
Sheldon: I submitted you a notarized list.
Amy: I'm sorry but "Gollum" and "Flakey" are not acceptable.
Sheldon: Well, you don't like Princess Corncob, you don't like Fester, you're just impossible to please.

Leonard: Look, even your friend Wil Wheaton thinks this is a waste of time.
Sheldon: Not true. Wil thinks this is a great idea. He was just concerned he wasn't a big enough celebrity to headline such an event. Also it's the same day he shampoos his beard.

Sheldon: Well, don't feel bad. I think we've all been distracted since the girls entered our lives.
Howard: You admit Amy's a distraction.
Sheldon: Oh very much so. Listen to this. This is from two days ago. "Hi, hope you're having a good day." Who has time for this constant sexting?

Howard: I haven't seen him laugh that hard since the day Leonard made that multiplication error.
Sheldon: Oh, Oh, Lord, that multiplication error! He thought he carried the one. But he didn't.
Leonard: It's not funny. That mistake got published.
Sheldon: Stop! I'm going to wet myself!

Sheldon: I don't think that will be necessary for Mr. James Earl Jones. You heard me. The voice of Darth Vader, The Lion King's dad and, FYI, the guy who says "This is CNN" - who also sounds like Darth Vader.

Emily: I'm a resident at Huntington Hospital.
Sheldon: Oh, I like their emergency room. You know, even if it turns out you don't have Dengue Fever, they still let you take a lollipop.

Howard: Since when do you read social science?
Sheldon: I go to the bathroom like everybody else.

Howard: He can't handle the fact that I'm a bigger deal than he is now.
Sheldon: Oh, preposterous. I have been solely responsible for this university's six loop quantum gravity calculations, I have changed the way we think about Bose-Einsten condensates, and I am also the one who got Nutter Butters in the cafeteria vending machine. Maybe you missed that news while you were floating around like a goof in outer space.

Sheldon: No, thank you. But for the record, I'm an excellent dancer. Proficient in the rumba, waltz and cha-cha.
Amy: Really?
Sheldon: I don't see why that's surprising. I excel at so many things. You've had my sourdough bread.

Sheldon: A girls night? Oh, I don't know if I'm up for an evening talking rainbows, unicorns and menstrual cramps.

Leonard: Sheldon, we have to do this.
Sheldon: No we don't. We have to take in nourishment, expel waste, and inhale enough oxygen to keep ourselves from dying. Everything else is optional.

Bernadette: Watch what happens when you move.
Sheldon: Oh! Oh, boy, you weren't kidding. Oh, those are 10,000 lumens if they're a lumen.
Howard: Well, you know what they say: when life give you lumens, make lumen-Ade. [chuckles]
Sheldon: Was that a joke?
Howard: Yes.
Sheldon: Based on the premise that "lumen" sounds like "lemon"?
Howard: Yes.
Sheldon: [chuckles] That's hilarious.