Sheldon: I need access to the Cheesecake Factory's walk-in freezer.
Penny: Now, honey, I already told you, the hamburger meat is fresh and stored at a safe temperature.

Raj: Is this just so we won't touch your stuff while you're away?
Sheldon: I'll admit that was a concern, but the fact is I'll need a support team, and the three of you are my first choice.
Howard: Really?
Sheldon: Well, there are others who might be more qualified, but the thought of interviewing them gave me a stomach ache.

Sheldon: Everyone at the university knows I eat breakfast at 8:00 and move my bowels at 8:20.
Leonard: Yes, how did we live before Twitter?

Howard: Easy. Instead of saying; 'No we don't wanna go on an NSF expedition,' say; 'No we don't wanna spend three months stuck in a cabin in the Arctic Circle with an anal nutbag!'

Sheldon: I'm a theoretical physicist, a career I chose in no small part because it's indoors. But if I'm able to detect slow-moving magnetic monopoles there, I will be the first scientist to confirm string theory. People will write books about me. Third-graders will create macaroni-art dioramas depicting scenes from my life.
Leonard: Sure, maybe a tableau of me trying to pummel you to death.

Sheldon: This is to train for a three month expedition to the magnetic North Pole.
Penny: What?!
Sheldon: I don't know how that sentence could possibly confuse you, but to elaborate, I'm going to the Arctic Circle with Leonard, Wolowitz and Koothrappali.

Leonard: Howard, this is big science. You could be the engineer who builds the equipment that puts us on the cover of magazines.
Howard: I could also be the engineer who builds the crossbow that kills Sheldon.

Penny: Leonard, I don’t know what to tell you. It was just a hug.
Leonard: Glad we cleared that up.
Penny: Yeah.
Leonard: I guess I'll see you.
Penny: Okay, have a safe trip.
Leonard: Thank you. Bye.
Penny: Okay, bye. [closes door] It means I wish you weren't going.

Raj: But mummy, all the other guys are going to the North Pole.
Mrs. Koothrappali: I don't care what the other guys are doing. If the other guys jumped in the Bay of Bengal and tried to swim to Sri Lanka, would you follow them?

Raj: Howard, wait. Why don't you use this instead of the PVC to keep the transverse filter assembly in place?
Howard: Because this is not a spare part from the space station. This is the thing from the pizza box that keeps the lid from touching the cheese.
Raj: That what that's for? In India, the lid just touches the cheese. Of course, we also have rampant poverty and periodic outbreaks of cholera, so a little cardboard in our cheese is no biggie.

Raj: Of course you feel terrible. You completely screwed up your karma, dude.
Sheldon: You don't really believe in that superstition, do you?
Raj: It's not superstition. It's practically Newtonian. For every action, there's an equal and opposite reaction. Leonard pretends to be a friend and acts like a two-faced bitch. Therefore, he is reborn as a banana slug. It's actually a very elegant system. You know, what goes around comes around.

Howard: Here's an approximation of the spare parts available on the Space Station. We gotta find a way, using nothing but this, to reinforce this so the waste material avoids the spinning turbine.
Raj: You mean so it doesn't hit the fan?

Sheldon: Why does Leonard get to go?
Wolowitz: Because he's upset over his situation with Penny, and if I have to hear about it again, I'm gonna kick him in his ovaries!
Leonard: Thanks for understanding.
Howard: I've got your back, sister!

Sheldon: Have you notified NASA?
Howard: No. Are you crazy? What am I gonna say? I screwed up your toilet and pretty soon there's gonna be crap floating all over your nice shiny space station?

Sheldon: For what it's worth, my mother says that when we deceive for personal gain, we make Jesus cry.