Amy: Sheldon, this isn't about ruing. This is about humbly accepting a great honor.
Sheldon: Amy, we won the Nobel Prize in Physics. Humility is for people who win the goofy Nobels like Literature, Economics and Peace.
Amy: Please tell me that's not in your speech.
Sheldon: Oh. I can cut it, but it's the only joke I have.

Howard: Somebody just peed in the big girl potty.
Bernadette: Oh, I'm so proud! It was her, right?
Howard: Yes.

Howard: You still feel good about leaving them with Stuart and Denise for a couple days?
Bernadette: I guess. I just hope we don't miss Michael's first words.
Howard: Or Stuart's last words.

Bernadette: Now, Michael, Mommy and Daddy are going away for a couple days, so if you're gonna say your first words, you got to do it now or wait till we get back.

Bernadette: You realize it's been years since we've got away just the two of us.
Howard: I know. I can't wait. Fancy hotel room. The big bed.
Bernadette: Yeah. We're gonna sleep our asses off.

Sheldon: Carbon. Hydrogen. Carbon. Carbon. And last but not least, carbon.
Leonard: This might be the glue talking, but that was a very pleasurable 139 and a half hours.
Sheldon: Agreed.

Leonard: Excuse me, but if I recall, you're the one who went out drinking with Sheldon, then came home and attacked me.
Penny: Attacked you? I said, "Do you wanna?"
Leonard: Yeah. I was helpless.
Penny: Uh-huh.
Leonard: So do you wanna?
Penny: Well, I can't get more pregnant.
Leonard: Mm-hmm. We'll see about that.

Amy: How about this: you can practice your acceptance speech while I try on the dress.
Sheldon: Ah, great. You can help me whittle it down to 90 minutes.

Leonard: What kind of DNA is this, anyway?
Sheldon: I was trying to design the genetic code of an advanced race of human being. One of my rare failures, actually.
Leonard: What went wrong?
Sheldon: The balls kept sticking to my pants.

Leonard: You pick up your dresses?
Amy: Yep. The tailor had to take mine in and let Penny's out. Best day of my life.
Sheldon: What about the day you met me?
Amy: I stand by my statement.

Amy: Do you want to go back to the apartment and see me try on my dress?
Sheldon: Shouldn't I see it for the first time at the Nobel ceremony?
Amy: It's not a wedding.
Sheldon: Okay. Well, give me a minute to think of another reason I don't want to see it.

Penny: Well, thank you guys so much for the clothes and the shoes, the plane tickets. You've been so generous.
Amy: Well, it's important that all of our friends get to share this moment with us.
Sheldon: And then for years to come, you can tell others you had a front-row seat to history. Although, technically, I think your seats are in the second row.

Leonard: Was Amy suspicious when they had to let your dress out?
Penny: No. She was so happy, she didn't even question it.
Leonard: Someone's gonna figure it out. Why don't we just tell people?
Penny: No, it's too early. I haven't even wrapped my head around it.
Leonard: I have. My head is wrapped.
Penny: Yeah, well if something else had been wrapped, we wouldn't be in this situation.

Leonard: Oh, don't slam the-
Sheldon: Don't slam the [gasps] That was exhilarating.

Sheldon: Oh. Hey, look, that's Bernadette.
Bernadette: [on CNN:] I can't tell you how many times Dr. Fowler was gonna give up and I would say to her, "Amy, as your best friend, I'm not gonna let you quit."
Penny: Okay, I'm drinking again.
Sheldon: I'll join you. Waitress, uh, 95% Hawaiian Punch, five percent vodka.
Howard: [on CNN:] Let me tell you about the time Mr. Nobel Laureate wanted olives.
Bernadette: [on CNN:] This is a good one.
Sheldon: You know what, 90/10!