Mary Cooper: It's all themed. There's Jonah and the Whale Watching. All-you-can-eat Last Supper Buffet. And my personal favorite, Gunning with God.

Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Howard: Sheldon, you're a condescending jerk. Why on earth would I want to do something nice for you?
Sheldon: To go to Jewish heaven.
Howard: Jews don't have heaven.
Sheldon: To avoid Jewish hell?
Howard: Have you met my mother? I live in Jewish hell.

Amy: Jewelry? Seriously? Sheldon, you are the most shallow, self-centered person I have ever met! Do you really think another transparently manipulative - Oh, it's a tiara! Put it on me, put it on me, put it on me, put it on me.

(Sheldon knocks on Penny's door three times)
Penny: Who do we love?
Sheldon: Penny. (Knocks 3 times)
Penny: Who do we love?
Sheldon: Penny. (Knocks 3 times)
Penny: Who do we love?
Sheldon: Penny.

Bernadette: I'm too small for Twister. And roller coasters. And sitting with my feet on the floor. Hope you enjoyed the prenatal cigarettes, Mom.

Penny: (Whispers) Here she comes.
Howard: Smart. Whisper so the deaf chick doesn't hear you!

Sheldon: I would have been here sooner but the bus kept stopping for other people to get on it.

Bernadette: Doesn't he know you have a boyfriend?
Penny: She doesn't have a boyfriend, she has a Sheldon.

Penny: You look beautiful.
Amy: Of course I do, I'm a princess and this is my tiara!

Howard: I thought you didn't like Facebook any more.
Sheldon: Don't be silly, I'm a fan of anything that tries to replace actual human contact.

(Howard has just told Mary about his upcoming trip to the International Space Station.)
Mary Cooper: I bet your mom is really proud of you.
Howard: Nope. She says if I don't back out, she's gonna go on a hunger strike. It'd take years before she'd be in any kind of danger, but still.

Leonard: Once you open the box it loses its value.
Penny: Yeah, yeah. My mom gave me the same lecture about my virginity. I gotta tell you, it was a lot more fun taking it out and playing with it.

Amy: You are aware that your ritualistic knocking behavior is symptomatic of obsessive-compulsive disorder?
Sheldon: Is not. Is not. Is not.
Amy: Denial. Denial. Denial.

Mrs. Wolowitz Howard Joel Wolowitz, I've been worried sick for two days and I know you turned off your phone. You open this door right now because I've had it up to here! I have been to the morgue and the hospital, and I spent the last half hour walking up these fakakta stairs.