Sheldon: Thank you, Dr. Fowler. I have a very long and somewhat self-centered speech here. But I'd like to set it aside.
Penny: Yeah!
Howard: Way to go!
Sheldon: Because this honor doesn't just belong to me. I wouldn't be up here if it weren't for some very important people in my life. Beginning with my mother, father, meemaw, brother and sister. And my other family, who I'm so happy to have here with us. Is that Buffy the Vampire Slayer? I was under a misapprehension that my accomplishments were mine alone. Nothing could be further from the truth. I have been encouraged, sustained, inspired and tolerated not only by my wife, but by the greatest group of friends anyone ever had. I'd like to ask them to stand. Dr. Rajesh Koothrappali. Dr. Bernadette Rostenkowski-Wolowitz. Astronaut Howard Wolowitz. And my two dearest friends in the world, Penny Hofstadter and Dr. Leonard Hofstadter. I was there the moment Leonard and Penny met. He said to me that their babies would be smart and beautiful. And now that they're expecting, I have no doubt that that will be the case.
Penny: Thanks, Sheldon. I-I haven't told my parents yet, but thanks.
Sheldon: Oh. I'm sorry. Don't tell anyone that last thing. That's a secret.
Howard, Bernadette, Raj, Penny, Leonard, I apologize if I haven't been the friend you deserve. But I want you to know in my way, I love you all. And I love you. Thank you.

Amy: I tried to ask him about it, and he invoked section three, article five of the marriage contract: beeswax, none of your.

Stuart: Whoa, whoa. You're not gonna cut open a meteor, are you? Have you not learned anything from comic books? Space viruses? Pod people? I sell nothing but warnings.

Stuart: Would you mind stocking these?
Denise: Actually, I'm not on the clock today. I'm just hanging out with my boyfriend.
Stuart: Ah, cool. Huh. That's me, right?
Denise: Oh, I forgot to tell you, I broke up with you, and now I'm dating that guy.
Stuart: I know you're joking, but my flight-or-flight response doesn't.
Denise: Isn't it fight-or-flight?
Stuart: Not for me.

Penny: So, I guess the only thing that actually stays the same is that things are always changing.
Sheldon: Interesting. So you're saying the inevitability of change might be a universal constant.
Penny: Well, there's a little more to it than that, but, yeah, sure.

Bernadette: Why do you want to ride that stupid thing anyway?
Howard: I don't know. Maybe I just miss the freedom I had as a younger man.
Bernadette: What freedom? You lived with your mother. You had a curfew.

Amy: Wow. Déjà vu.
Sheldon: Amy, you're a neuroscientist. you know the latest research into déjà vu suggests it's nothing but the frontal regions of the brain attempting to correct an inaccurate memory.
Amy: You telling me stuff I already know is definitely déjà vu.

Sheldon: Thanks, Dad. We're gonna give them hell.

Sheldon: Carbon. Hydrogen. Carbon. Carbon. And last but not least, carbon.
Leonard: This might be the glue talking, but that was a very pleasurable 139 and a half hours.
Sheldon: Agreed.

Sheldon: How can I tell if I'm doing something for a noble reason or a selfish reason?
Amy: Try saying the thing in your head and see if you can add the words, "That'll show 'em."

Amy: Oh. That's me. Hello? Yes, this is Dr. Fowler. I see. Okay, thank you. We won.
Penny: Congratulations!
Leonard: Oh, my God!
Sheldon: We did it.
Amy: I know. Can you believe it?
Sheldon: That's a good point. What if I'm dreaming? [Leonard slaps Sheldon] We won the Nobel Prize!

Penny: Where does Sheldon think you are?
Amy: Oh, Sheldon's kind of like a dog, he doesn't really think about me when I'm gone, but he's so happy when I show up.

Amy: How's this for a compromise? Make all the schedules you want, just don't tell me about them.
Sheldon: Excellent. I'll create an algorithm that'll generate a pseudo-random schedule.
Yeah, and do you know why it won't be a true random schedule?
Amy: Because the generation of true random numbers remains an unsolved problem in computer science.
Sheldon: Come with me.
Amy: Where are we going?
Sheldon: To the hotel room. And when we get there, I'm gonna need you to say that again, except naked.

Leonard: It's a pep talk he made when he was a kid. He gave it to me years ago and told me to save it for a real emergency.
Penny: What? You didn't break it out when he declared his room a sovereign nation and waged a trade war against us?
Leonard: His major export is talking. I didn't want that anyway.

Amy: Okay, all hooked up. Here we go. Oh, look how cute you were!
Sheldon: Amy, please, of course I was cute. Look how I turned out.