Sheldon: Sheldon Cooper does not get lucky.
Amy: You and me both, brother.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Amy: Do you have any idea how hard it is to laugh at a knock knock joke that starts "Knock Knock Knock, Amy. Knock Knock Knock, Amy. Knock Knock Knock, Amy"?

Amy: I guess it must have been back when I was in the Girl Sprouts.
Bernadette: Girl Sprouts?
Amy: My mom made it up as an alternative to the Girl Scouts. She didn't want me selling cookies on some street corner like a whore.

Penny: [to Raj] Run to India.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Penny: Howard, cow tipping - real or not?
Howard: I'm going to say not. That's just based on me trying to roll my mom over when she's snoring.

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Amy: As my mom used to say, "When you're doing a puzzle, it's like you've got a thousand friends." She was full of fun lies like that.

Sheldon: I know why. You've come to me because you're my Obi-Wan.
Arthur: I'm not familiar with that. Is that an Internet?

Penny: If you guys were hungry, why didn't you order something at the restaurant?
Bernadette: We did. You never brought it.
Penny: Oh, that's right. Nachos and a turkey club.
Amy: Not even close.
Penny: Well, I was too busy standing up for my friend to worry about your ... I want to say salmon.
Amy: You want to say sorry.

Raj: It's too late. He's been murdered by someone in this room. Welcome to another classic Koothrappali murder mystery dinner.
Amy: I'm leaving.

Howard: So you can never take it (the sweater) off?
Leonard: No.
Raj: Not even to sleep?
Leonard: No.
Howard: So you're just an idiot?
Leonard: It's called proving a point.
Howard: Is the point you're an idiot?