Raj: Amy, good luck getting these guys excited about a dinner with a theme. I gave up when no one cared about my Tom Hanks-Giving.

Howard: Don't feel bad. Some day someone will be throwing out your work, too.
Leonard: That someone was Sheldon and the day was yesterday.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Bernadette: She's just being nice.
Howard: Well, I'm her son, how come she doesn't send someone to check on me if I'm lonely.
Bernadette: Because you have a wife!
Howard: Yeah, well, sometimes you work late.

Amy: This is an easy one. You love this guy.
Sheldon: Me.
Amy: Come on. He's an under appreciated genius.
Sheldon: Still think it's me.
Amy: It's not you. Now think, there's a car named after him.
Sheldon: Of course there is. The Mini Cooper because it's me.
Amy: How about this? He's a poor man's Sheldon Cooper.
Sheldon: Oh, Tesla.

Sheldon: Ignore them, Amy. They're just jealous because they'll never have a relationship as good as ours.
Penny: Isn't this when he says "bazooka" or something?

Sheldon: May I say something?
Leonard: Not right now, Sheldon.
Sheldon: But I think it may be comforting.
Leonard: Buddy-
Howard: No, it's okay. What?
Sheldon: When I lost my own father, I didn't have any friends to help me through it. You do.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Bernadette: You better find my husband's mother, 'cause one way or another we're walking out of this airport with a dead woman.

Penny: Why are there tears?
Leonard: Everything's fine. We just started talking about living arrangements.
Amy: Are you crazy? You know he's a flight risk!
Sheldon: That's exactly what I told him.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Sheldon: I know the real reason you never made progress with that idea. You thought of it September 22nd, 2007. Two days later, Penny moved in and so much blood rushed to your genitals, your brain became a ghost town.

Wil Wheaton: You know that the movie actually has a little bit of a cult following.
Penny: Really?
Wil Wheaton: Yeah. I was at a science-fiction convention, and I saw a woman dressed as your half-ape character.
Leonard: Oh, if she was with an Indian guy dressed like a banana, that was just my friends, Howard and Raj.

Sheldon: It reminds me of when my stupid brother and sister would build forts in the living room, and wouldn't let me in. I hated that so much.
Amy: You know, there's nothing I can do about getting you invited to the symposium, but if you wanted we could build a fort.
Sheldon: Isn't that a little juvenile?
Amy: More juvenile than this? *Puts up picture of smiling Sheldon to her face*