Sheldon: I'd like to take a moment to personally thank Dr. Amy Farrah Fowler, who you may or may not know is the first woman to co-host a flag or banner related Internet infotainment show.
Amy: Take that glass ceiling!

Raj: Okay, here we go. [to Leonard & Penny] Say cheese. [to Sheldon & Amy] Say cheese. [to Howard & Bernadette] Say cousin.

Sheldon: There's no denying that I have feelings for you that can't be explained in any other way. I briefly considered that I had a brain parasite, but that seems even more far-fetched. The only conclusion was love.

Sheldon: Can I respond now?
Leonard: Do it.
Sheldon: You mess with the bull, you get the horns. I'm about to show this guy just how horny I can be.
Leonard: Somebody else do it.

Penny: Do I really force you to do things you don't want to?
Amy: Yeah, but it's okay.
Penny: How is it okay?
Amy: I promised myself if I ever got friends I'd do whatever they said. Really, I'm lucky you found me before a cult did.

Sheldon: I'm exceedingly smart. I graduated college at fourteen. While my brother was getting an STD, I was getting a Ph.D. Penicillin can't take this away.

Leonard: You know what, this bottle was meant to celebrate an achievement. Let's make a pact. When one of us gets their first big breakthrough, we'll celebrate by opening this bottle and toasting Professor Abbott.
Howard: I love that.
Raj: Me too.
Leonard: Then, of course, rubbing our success in Sheldon's face.
Howard: Well that's the best part.

Stuart: I'm not bringing your mother. I have a date.
Howard: Oh, so now you're cheating on my mother.

Sheldon: Thank you for understanding.
Amy: Of course I understand. Sheldon, there's something else I've been wanting to say, but before I do, I just. I want you to know you don't have to say it back. I know you're not ready and I don't want you to say it just because social convention dictates -
Sheldon: I love you, too.
Amy: You said it.

Sheldon: I know the real reason you never made progress with that idea. You thought of it September 22nd, 2007. Two days later, Penny moved in and so much blood rushed to your genitals, your brain became a ghost town.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Leonard: So, for the remainder of my speech, this is for the invisible kids. Maybe you never fit in. Or maybe you were the smallest kid in the school. Or the heaviest. Or the weirdest. Maybe you're graduating and you still haven't even had your first kiss. By the way, nineteen, and Geraldine Coco, wherever you are, thank you. Maybe you don't have any friends, and guess what, that's okay. While all the popular kids are off doing whatever - I don't know what they're doing because I was never there.

Amy: Have you made a decision about the TARDIS? I think I can sell it if we call it Big British Portapotty.

Penny: Ooh, we could go horseback riding.
Amy: I actually can't. My hips don't open wider than 22 degrees. I rode a very thin pony once. On the first bump I just popped right off.

Sheldon: I have some odd freckles on my buttocks. Can I make an appointment for you to look at them?
Emily: Erm, okay, I guess.
Amy: I'm with him three years, nothing. She's with him two minutes and he's taking his pants off.