Raj: Amy, good luck getting these guys excited about a dinner with a theme. I gave up when no one cared about my Tom Hanks-Giving.

Sheldon: I know the real reason you never made progress with that idea. You thought of it September 22nd, 2007. Two days later, Penny moved in and so much blood rushed to your genitals, your brain became a ghost town.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: May I say something?
Leonard: Not right now, Sheldon.
Sheldon: But I think it may be comforting.
Leonard: Buddy-
Howard: No, it's okay. What?
Sheldon: When I lost my own father, I didn't have any friends to help me through it. You do.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: Ignore them, Amy. They're just jealous because they'll never have a relationship as good as ours.
Penny: Isn't this when he says "bazooka" or something?

Leonard: Well, you can spend the rest of the day being bitter about this--
Sheldon: Agreed.
Leonard: I was going to say "or," but why bother?

Amy: Can you see how a grown man and accomplished scientist who invests in a store that sells picture books about flying men in colorful underwear might be wasting both his financial and intellectual resources?
Sheldon: No.
Amy: Then I think it's a terrific idea.
Sheldon: Great! Wait until you hear about our van.

Penny: Hey, I don't think she's wrong about you going too slow in the relationship.
Sheldon: Too slow?
Penny: Yeah, you've been going out for years. You haven't even slept together.
Sheldon: That's right. It's called foreplay.

Howard: Don't feel bad. Some day someone will be throwing out your work, too.
Leonard: That someone was Sheldon and the day was yesterday.

Bernadette: You better find my husband's mother, 'cause one way or another we're walking out of this airport with a dead woman.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: She's just being nice.
Howard: Well, I'm her son, how come she doesn't send someone to check on me if I'm lonely.
Bernadette: Because you have a wife!
Howard: Yeah, well, sometimes you work late.

Sheldon: It reminds me of when my stupid brother and sister would build forts in the living room, and wouldn't let me in. I hated that so much.
Amy: You know, there's nothing I can do about getting you invited to the symposium, but if you wanted we could build a fort.
Sheldon: Isn't that a little juvenile?
Amy: More juvenile than this? *Puts up picture of smiling Sheldon to her face*