Sheldon: We're scientists, we can conduct our own research. I propose that we imprison two street people-
Amy: No.
Sheldon: You didn't even let me finish.
Amy: Forget it.
Sheldon: Oh, so you can experiment on all the apes you want, but I want to manipulate the emotions of two captive human beings, suddenly I'm the monster.

Sheldon: As a Texas gentleman, I'm inclined to say ladies first. Although, I'm concerned that level of politeness and charm may make you fall in love with me before the test even begins.

Sheldon: As much as I'd love to meet Euclid, inventor of the geometric proof, he probably wore sandals and I can not look at toes during dinner.

Howard: How'd you get him to come to your house?
Sheldon: As Professor Proton always says, there is no problem you can't solve if you use your noggin.
Leonard: And he wrote him a check.
Sheldon: Yeah, that too. A big check.

Amy: Maybe you'll like living alone.
Sheldon: Perhaps.
Amy: And if you don't, maybe you and I could live together.
Sheldon: Oh, sure! While we're at it, why don't we get engaged, too? Why don't we get a little house, start a family, enjoy our sunset years together? Do you hear yourself woman?!

Sheldon: Given our new found intimacy, I'd say we have some hard choices to make.
Penny: Like what?
Sheldon: Gary Con. Do we fly or drive? Do we wear costumes? And if so, who gets to be Gary?

Sheldon: *knock knock knock* Penny! *knock knock knock* Penny! *knock knock knock* Penny!
Penny: Sheldon, go away. I'm making a video.
Sheldon: Oh, I'm sorry. I'll come back when you're alone.

Sheldon: We might as well stop. It's a stalemate. You're beating me at tetris, but you've got the upper body strength of a Keebler Elf.

Leonard: You having a good day?
Penny: No, I missed an audition because my computer broke, and I didn't get the e-mail. Would've been a perfect part for me.
Sheldon: Was it waitress who ignores her customers? Because that's the role you were born to play.
Penny: Shut up and eat your burger.
Sheldon: Actually, it's a turkey club.
Penny: Didn't you order a burger?
Sheldon: I did, and yet here we are.

Amy: You know, this might work out for the best. You're always complaining about what a terrible roommate Leonard is. Like how he turns up the thermostat when you're not there.
Sheldon: Euck, it's like walking into the Amazon. And not the good Amazon with one-day shipping, the awful one with birds and snakes.

Sheldon: I will play the word "at" for two measly points, throwing the game and thus securing my friendship with the smartest man in the world.
Howard: What are you waiting for? Hit send.
Sheldon: I can't. Losing on purpose is intellectually dishonest.
Raj: So don't do it.
Sheldon: Oh, but I want to be Hawking's friend.
Howard: So do it.
Sheldon: Oh, but if I do, I'll be a phony, a sellout, a Hollywood poser.
Raj: Then don't do it.
Sheldon: I won't. This feels right. My mother always said, to thine own self be true.
Howard: Good for you.
Sheldon: 'course she also told me that every animal in the world got on one boat, so what does she know? And send.

Amy: I know we only have coitus on my birthday, but I don't know if I can wait until midnight.
Sheldon: Oh, well, you'll be glad you did. Everyone knows the best foreplay is rigid adherence to a strict schedule.

Penny: What's yours?
Sheldon: I wake up. I enjoy some french toast with butter and syrup. Then a wormhole opens and whisks me millions of years into the future, where my towering intellect is used to save the last remnants of mankind from a predatory alien race.
Penny: Interesting you didn't mention Amy.
Sheldon: Who do you think made the french toast and syrup?

Sheldon: Oh really, Leonard? Are you going to have another one of your hissy fits?
Leonard: Hissy fits? I have hissy fits?
Sheldon: Yes, and I have a theory why. Because of your lactose intolerance, you switched over to soy milk. Soy contains estrogen-mimicking compounds. I think your morning Cocoa Puffs are turning you into a hysterical woman.

Penny: I meant has he ever been involved with someone who wasn't a brainiac?
Sheldon: Oh! Well, a few years ago, he did go out with a woman who had a Ph.D in French Literature.
Penny: How is that not a brainiac?
Sheldon: Well, for one thing she was French.