Sheldon: We could also stop using the letter M. But I think that idea is isguided and oronic.

Sheldon: No one calls me Moon Pie but Meemaw.

Penny: Mmm, what smells so good?
Sheldon: That is the intoxicating aroma of Kadhai Paneer. A perfect culinary representation of the freedom this evening holds. Not only is it Indian cuisine, which Koothrappali loathes, it contains a generous helping of peanuts, which would reduce Wolowitz to a wheezing 97-pound blister. And finally, its main ingredient is paneer, a farmer's cheese that would cause Leonard to render any room uninhabitable within minutes.

Amy: I was proposing massaging your muscles with your own hands.
Sheldon: Still sounds like a lot of unnecessary touching.

Howard: (Repeating what Raj says) You're right, Penny jogs. Maybe you guys can run together.
Sheldon: That's an excellent idea. Yeah, if we chat, it will create the illusion of time going faster.
Penny: No, it won't.

Sheldon: What's the sixth noble gas?
Leonard: Uh, radon?
Sheldon: Are you asking me or telling me?
Leonard: Telling you?
(Sheldon gives Leonard a stern look)
Leonard: Telling you.

Bernadette: I like the Wii.
Sheldon: Thanks, Grandma.

Sheldon: I believe the appropriate metaphor here involves a river of excrement and a Native American water vessel without any means of propulsion.

Leonard: It wasn't until his twenty-first birthday that 1955 Biff placed his first bet.
Sheldon: Wow wow wow. Is 'placed' right?
Leonard: What do you mean?
Sheldon: Is 'placed' the right tense for something that would have happened in the future of a past that was affected by something from the future?
Leonard: 'Had will have placed'?
Sheldon: That's my boy.

Sheldon: I don't mean to be rude or discourteous, but before we begin. I'd just like to say there's absolutely no scientific evidence to support clairvoyance of any kind. Which means - and again, no insult intended - you're a fraud, your profession is a swindle, and your livelihood is dependent on the gullibility of stupid people. But again, no offense.

Sheldon: Wow, pouting and running away actually worked. I must say that may not be a lesson you want to reinforce with me.

Cop: Your friend called 911 to report a robbery.
Leonard: Oh, my God, what did they get?
Sheldon: What didn't they get? They got my enchanted weapons, my Vicious Gladiator armor, my Wand of Untaimed Power and all my gold.

Howard: No, we can still make this work. Leonard, you talk to Penny.
Leonard: What makes you think I can convince her?
Howard: You got her to have sex with you. Obviously, your superpower is brainwashing.
Leonard: Okay, let me see if I understand this. You want me to convince my ex-girlfriend to go to a costume party with her new boyfriend just so we can win a stupid prize?
Sheldon: Yes. And make her wear the black wig. Good luck.

Sheldon: According to the inexplicably irritable nurse behind the desk, you'll be seen after the man who claims to be having a heart attack, but appears to be well enough to play Doodle Jump on his iPhone.

Sheldon: Leonard, are you in the shower?
Leonard: I can't hear you, I'm in the shower.
Sheldon: I asked if you were in the shower, but that's moot now.
Leonard: What?
Sheldon: Moot. Rendered unimportant by recent events.
Leonard: I can't hear you, I'm in the shower.
Sheldon: (Entering bathroom) I have to skip the chitchat. Emergency!
Leonard: What kind of an emergency?
Sheldon: Mathematical. 32 ounce banana smoothie, 16 ounce bladder.