Sheldon: Good news, gentlemen. Amy's at a conference this weekend, which means I'm available to be entertained, hmm. As today's youth might put it: Who wants to get their Sheld-on?

Sheldon: I have an eidetic memory. I don't what his (Raj's) problem is.

Sheldon: Ten years ago upon first seeing me, your husband claimed that I looked like C3P0 and Peewee Herman. And he called me C3Peewee Herman.

Amy: Hey, good news. They're inviting several Nobel Laureates to our reception.
Sheldon: Oh, great, like who?
Amy: Uh, Makoto Kobayashi.
Sheldon: Ooh.
Amy: What?
Sheldon: Well, I may have been less than kind to him about his Nobel Prize win.
Amy: Why?
Sheldon: I was jealous, angry and new to Twitter. It was a dangerous combination.
Amy: Okay, so scratch Kobayashi.

Leonard: No, her bed kind of ... broke.
Sheldon: That doesn't seem likely. Her bed's of sturdy construction. Even the addition
of a second normal size human being wouldn't cause a structural failure, much less a homunculus such as yourself.
Penny: A homunculus?
Leonard: Perfectly formed miniature human being.

Sheldon: You're awfully quiet.
Leonard: Sorry.
Sheldon: No, I like it.
Leonard: Got a lot on my mind.
Sheldon: Would you like to talk about it?
Leonard: Not really.
Sheldon: Grape Nuts for breakfast, quiet car ride, things are really breaking my way today.

Sheldon: And worse than that, Edison filmed the first on-screen kiss, so he's basically a pornographer. Although every time I put that in Wikipedia, someone takes it out.

Sheldon: We're trying to think down here, you geode-loving feldspar jockeys!

Amy: Okay, what's the next test?
Sheldon: Loyalty. We need to choose someone who has our backs, someone who will keep our secrets even from each other.
Amy: Well, I don't have any secrets from you. Do you have secrets from me?
Sheldon: Yes. Oh, that has been weighing on me for years.

Sheldon: Howard, I've had my eye on this limited edition Swamp Thing, but now that I'm about to buy it, I'm having second thoughts. What do you think?
Howard: I don't know, Sheldon, it's pretty expensive.
Sheldon: Yes, but what if it will make me happy, you know, waking up and seeing it every morning for the rest of my life?
Howard: Really, a walking clump of swamp grass?
Sheldon: Yeah, well, Bernadette's no prize either!

Sheldon: It's not the same thing. I don't think you know how I feel at all.
Leonard: Sad?
Sheldon: Hmm, you do get me.

Bernadette: So your evil plan here is to buy your girlfriend a present?
Sheldon: That's right. So stay on my good side, or maybe I'll get you a little something, too.

Amy: It's weird. I don't really feel different, but I guess our lives will never be the same.
Sheldon: Oh, I don't know. We're going to work like always. I still put my pants on both legs at a time.
Amy: One day that's gonna end very badly.

Sheldon: Now to business. Eighteen years ago, I sent the FBI Crime Lab samples from a bag of excrement that had been lit on fire on my front porch for fingerprinting and DNA analysis. Why haven't I heard back yet?
Agent Page: Well, the FBI Crime Lab does have a lot on its plate.
Sheldon: That's of little comfort to a nation attempting to scrape burning faeces off its shoes.

Sheldon: You just lied to Penny.
Leonard: Yes, I did.
Sheldon: And you did it so casually. No rapid breathing, no increase in perspiration.
Leonard: So?
Sheldon: So, lack of physiological response while lying is a characteristic of a violent sociopath.
Leonard: Sheldon, are you worried about your safety?
Sheldon: No. I imagine if you were going to kill me, you'd have done it a long time ago.