Leonard: You pick up your dresses?
Amy: Yep. The tailor had to take mine in and let Penny's out. Best day of my life.
Sheldon: What about the day you met me?
Amy: I stand by my statement.

Leonard: Are you kidding me? You just found out that a woman who has loved and cared for you for 12 years is pregnant, and all you can say is you're relieved that she's not gonna get you sick?
Sheldon: There's no need for a recap. I was there.

Penny: Well, thank you guys so much for the clothes and the shoes, the plane tickets. You've been so generous.
Amy: Well, it's important that all of our friends get to share this moment with us.
Sheldon: And then for years to come, you can tell others you had a front-row seat to history. Although, technically, I think your seats are in the second row.

Sheldon: All right, well, we should head out now if we're gonna get to the airport six hours before boarding.

Amy: Sheldon, this isn't about ruing. This is about humbly accepting a great honor.
Sheldon: Amy, we won the Nobel Prize in Physics. Humility is for people who win the goofy Nobels like Literature, Economics and Peace.
Amy: Please tell me that's not in your speech.
Sheldon: Oh. I can cut it, but it's the only joke I have.

Howard: Oh, good, you're here. Listen, we're thinking maybe we should go back to L.A.
Amy: Why?
Howard: We just can't be this far away from the kids. Bernie's having a meltdown, and, frankly, so am I.
Sheldon: Yeah, well, pull it together. This is a big day for me.
Howard: [scoffs] Yeah, I wasn't sure what to do. Now I am. We're going home.
Leonard: We'll join you.
Penny: Oh, wait. Do I get a vote in this?
Leonard: They'll have pickled herring on the plane.
Penny: Bye-bye.

Sheldon: Thank you, Dr. Fowler. I have a very long and somewhat self-centered speech here. But I'd like to set it aside.
Penny: Yeah!
Howard: Way to go!
Sheldon: Because this honor doesn't just belong to me. I wouldn't be up here if it weren't for some very important people in my life. Beginning with my mother, father, meemaw, brother and sister. And my other family, who I'm so happy to have here with us. Is that Buffy the Vampire Slayer? I was under a misapprehension that my accomplishments were mine alone. Nothing could be further from the truth. I have been encouraged, sustained, inspired and tolerated not only by my wife, but by the greatest group of friends anyone ever had. I'd like to ask them to stand. Dr. Rajesh Koothrappali. Dr. Bernadette Rostenkowski-Wolowitz. Astronaut Howard Wolowitz. And my two dearest friends in the world, Penny Hofstadter and Dr. Leonard Hofstadter. I was there the moment Leonard and Penny met. He said to me that their babies would be smart and beautiful. And now that they're expecting, I have no doubt that that will be the case.
Penny: Thanks, Sheldon. I-I haven't told my parents yet, but thanks.
Sheldon: Oh. I'm sorry. Don't tell anyone that last thing. That's a secret.
Howard, Bernadette, Raj, Penny, Leonard, I apologize if I haven't been the friend you deserve. But I want you to know in my way, I love you all. And I love you. Thank you.

Sheldon: Leonard we need to do something about your wife.
Leonard: What's the matter?
Sheldon: She is clearly sick, and she's gonna take us all down with her.
Leonard: She's not sick, Sheldon.
Sheldon: She is, and I'm gonna catch it, and it's gonna ruin the greatest day of my life.
Leonard: I promise you're not going to get what she has.
Penny: What's going on?
Sheldon: [gasps] Unclean! Unclean!
Penny: What?
Leonard: He thinks you're sick.
Penny: Oh. Should we tell him?
Leonard: Well, if we don't, he might try and jump out of the plane.
Penny: Yeah. Doesn't answer my question.

Bernadette: You realize it's been years since we've got away just the two of us.
Howard: I know. I can't wait. Fancy hotel room. The big bed.
Bernadette: Yeah. We're gonna sleep our asses off.

Leonard: How long is it gonna take you to get ready?
Penny: Oh, I just need, like, five or ten minutes.
Leonard: Really?
Penny: No. What is wrong with you?!

Sarah Michelle Gellar: Just to be clear, this isn't a date.
Raj: Yeah, I know.
Sarah Michelle Gellar: Then why are you holding my hand?

Sheldon: Well done. You know, you're proving to be an invaluable part of my entourage.
Leonard: Cool.

Amy: Thank you, your majesties. Thank you to the Nobel Committee. We are deeply honored. I would just like to take this moment to say to all the young girls out there who dream about science as a profession: go for it. It is the greatest job in the world. And if anybody tells you you can't, don't listen. And now, speaking of not listening, my husband, Dr. Sheldon Cooper.

Howard: You still feel good about leaving them with Stuart and Denise for a couple days?
Bernadette: I guess. I just hope we don't miss Michael's first words.
Howard: Or Stuart's last words.

Amy: What happened to "I'm never gonna have kids"?
Penny: It was an accident. I went out drinking with Sheldon.
Amy: [gasps] Oh, my gosh. We're sister wives?
Penny: No! Then I went home and slept with Leonard.
Amy: While fantasizing about-
Penny: Leonard. And a little Idris Elba.