Leslie: Hello men. Sheldon.

Dr.Gablehauser: Need to get that, Dr. Cooper?
Sheldon: God, no.
Leslie: Don't turn it off, you might miss the Nobel Prize Committee saying that you won "Dumbass Scientist of the Year."

Leonard: Wanna catch me up?
Sheldon: Well, let's see. She attempted to open her apartment with her car key because her face is overly Midwestern. She hasn't had sex in 6 months, and she ate a fly.
Leonard: Uh-huh. Seriously, 6 months?

Sheldon: Level 3 and she thinks she's rich. What a noob!

Sheldon: Fellow warriors, this is Sheldor the Conqueror. We are about to enter Atzel's fortress. Now, this is a long run, so let's do another bladder check. All right, Barry, we'll wait for you again, but you really should see a doctor.

Sheldon: Just when I think I've gotten the hang of sarcasm.

Sheldon: You're in my bedroom.
Penny: Yeah, Leonard gave me an emergency key.
Sheldon: People can't be in my bedroom.

Penny: Can we go talk in the living room?
Sheldon: I'm not wearing pajama bottoms.
Penny: Why not?
Sheldon: I spilled grape juice.
Penny: Well, wear different pajamas.
Sheldon: I can't wear different pajamas. These are my Monday pajamas.

Tom: I'm sorry, dude, she didn't look anything like her picture.
Leonard: They never do.

Sheldon: Sheldor, back online.
Penny: What's AFK?
Sheldon: AFK. Away from keyboard.
Penny: Oh, I see.
Sheldon: What does that stand for?
Penny: "Oh, I see"?
Sheldon: Yes, but what does it stand for?

Sheldon: The Hungarians are just using you for dragon fodder.
Penny: Really? Boy, you'd think you could trust a horde of Hungarian barbarians.

Leonard: Why should I do something? You're the one who introduced her to online gaming.
Sheldon: Well, yes, but you're the one who said hello to her when she moved in. If you'd just simply restrained yourself, none of this would be happening.

Leonard: Why don't you just tell her to leave you alone?
Sheldon: I did. I told her, I texted her, I sent out a very emphatic Twitter. I even changed my Facebook status to Sheldon Cooper wishes Penny would leave him alone. I don't know what else to do.

Sheldon: Would it be possible for you to do this a little more quietly?
Penny: I can't get the damned key out.
Sheldon: Well that's not surprising. That Baldwin lock on your door uses traditional edge-mounted cylinders, whereas the key for your Volkswagon uses a center cylinder system.
Penny: Thank you, Sheldon.
Sheldon: You're welcome.

Sheldon: Point of inquiry, why did you put your car key in the door lock?
Penny: Why? I'll tell you why. Because today I had an audition, it took me two hours to get there, I waited an hour for my turn, and before I could even start they told me I looked too Midwest for the part. Too Midwest? What the hell does that even mean?
Sheldon: Well, the American Midwest was mostly settled by Scandinavian and Germanic peoples who, well they have a characteristic facial bone structure...
Penny: I know what it means, Sheldon!