Sheldon: 366, 367
Amy: How's it going?
Sheldon: How's counting going? When I was in kindergarten, I recited Pi to a thousand places for the school talent show. I think I got this.
Amy: Great.
Sheldon: Aw, nuts! One

Sheldon: This is preposterous. I think you're giving me these tasks because you're afraid if you give me anything meaningful to do, I'll show you up.
Amy: Really? Is that what you think?
Sheldon: Yes, that's what I think. And I'm super smart, so it's probably true.

Amy: Hey, I've been training in the field of neurobiology for 12 years. You've been here for three hours, and you've spent one of them in the bathroom.
Sheldon: I'm sorry. It takes me a while to get things going on an unfamiliar toilet.

Amy: Sheldon, I've given you the simplest things to do, and you haven't done one of them right.
Sheldon: Maybe that's because I'm not being challenged. It's the same reason Einstein failed math.
Amy: Maybe the math was too bubbly for him.
Sheldon: You think you're doing science by cutting up that brain? They could do the same thing at any Quiznos. And they'd offer to toast it for me, too.

Amy: Okay, smart guy. I'm about to remove the locus coeruleus, which is incredibly delicate work. Have at it.
Sheldon: All right. I'm no stranger to a little gray matter. Locus coeruleus. Locus coeruleus.
Amy: You're getting warmer, it is, indeed, in the brain. Hope your hands are steady. It's the width of a single hair. But this is just biology, so I'm sure it's no problem for a genius like you.
Sheldon: It's not. I'll have you know, in the field of physics, we work with particles so small, they make fat jokes about the locus coeruleus, i.e., when your locus coeruleus sits around the house, it sits around the house.

Sheldon: Does a locus coeruleus normally bleed that much?
Amy: No. But your thumb does.
Sheldon: Oh, dear. (Faints)

Howard: What happened to your thumb?
Sheldon: You know, I have ten fingers and ten toes. If I tell you a story about each one of them, we'll be here all day, let's just move on.

Sheldon: Ah, seeing as I'm on vacation, a pina colada seems appropriate. Extra pineapple slices, extra whipped cream, extra cherries, extra umbrellas, and, uh, hold the rum. Don't let me have too many of those.

Sheldon: I was kind of hoping I could continue vacationing in your laboratory. After all, I did book the whole week.
Amy: Do you honestly think you can just waltz back in here after the way you behaved yesterday?
Sheldon: I was not myself. I had lost a lot of thumb blood.
Amy: That's not an apology.
Sheldon: That is your opinion.

Amy: I want a real apology.
Sheldon: Im sorry that you weren't able to..
Amy: No.
Sheldon: That my genius...
Amy: No.
Sheldon: That the soap was...
Amy: Sheldon.
Sheldon: Fine. Sorry.
Amy: You're forgiven.

Amy: Now, if you want to stay, get started on those beakers. They're still dirty from yesterday.
Sheldon: Next year I'm going to Epcot.

Raj: Hey, look, there's Rothman's empty office. Sad.
Leonard: Yeah.
Sheldon: Mm, indeed.
Howard: So sad.
Sheldon: Dibs.

Bernadette: (Looking at the painting Amy bought Penny) That is big.
Penny: So big.
Bernadette: And ugly.
Penny: So ugly.

Penny: What am I gonna do?
Bernadette: I don't know. You can't take it down. You'll break her heart. Look at that face. That enormous, unsettling, crazy face.
Penny: Is there any chance I'll learn to love it?
Bernadette: That depends. Do you like pictures of yourself where you look like a man?

Penny: All right, it's got to go.
Bernadette: What will you tell Amy?
Penny: How about I tell her the painting makes you feel jealous because you're not in it?
Bernadette: Nuh-uh. What if she gets me one? I already have a picture of me and Howard's mom getting our hair cornrowed in Venice Beach. I've suffered enough.