Sheldon: (Running from the angry mob) Why is there never a pontoon plane when you need one?

Sheldon: Koko learned to understands over 2000 words, not one of which had anything to do with shoes.

Kripke: I'm Barry Kripke and I'm here because you told me there was a raffle. Where is the raffle?
Sheldon: Patience, patience, Barry, the waffle-- ahem. The raffle... is the grand finale to an evening-long festival of fun and folly.
Kripke: One more question--
Sheldon: Yes, you must be present to win.

Sheldon: Goodnight puny human!

Sheldon: You want some mutton and coconut milk?
Amy: No.
Sheldon: Boy I can not give this stuff away.

Sheldon: Oh, this again. So Penny proposed, you didn't say yes, and now you think you may have lost her love forever. How does this compare to me being forced to relax for a few days?
Leonard: It doesn't!
Sheldon: Thank you.

Amy: Why'd you pop it?
Sheldon: Sorry, I was aiming for your heart.

Sheldon: Ladies.
Penny: What's up?
Sheldon: As you may know, I have been experimenting with elevated anxiety levels, and I thought what better way to increase my discomfort than to subject myself to an evening of tasteless, uncensored crotch talk.

Penny: I thought you were looking at a cliff on the beach.
Amy: We were, but Sheldon didn't like any of them. Some were too beachy, some were too cliffy.
Sheldon: And all of them were too outsidey.

(Leonard standing outside the door to Sheldon and Amy's apartment)
Leonard: Help! Cinnamon's loose in the building!
Sheldon: (Inside) Amy, quick, lock the door!

Sheldon: So that's all this day was? A plan to butter me up before delivering bad news?
Leonard: Come on, buddy.
Sheldon: No, I thought we were friends. You asked for a sip of my Icee. If you had your own straw, I might've said yes.

Sheldon: I always looked up to you and Pop-Pop. I know what a challenging man he could be, but I saw you stand by him and make him into a better person.
Meemaw: I did.
Sheldon: Yeah, well, that is exactly what I've been doing the last five years with this little work in progress.
Leonard: He never disappoints, does he?

Leonard: Maybe you should consider women who aren't in serious relationships with your closest friends?
Sheldon: There's that prostate doctor, but I'm still mad at her.

Amy: What's with the blinking?
Sheldon: It's Morse code. So we can talk about without hurting --'s feelings.
Amy: Sheldon, I don't know Morse code.
Howard: I do. And if you have something to say, you can say it to my face.

Sheldon: What is it?
Amy: Well, your birthday's coming up and you've never let us celebrate it. And I was hoping maybe this year we could.
Sheldon: Oh, I suppose that's a discussion we could have. (Sheldon runs back up the stairs)
Amy: Okay, great, I mean, it doesn't have to be a big party or anything. I was just - Where'd he go?