Sheldon: I don't care for novelty editions of Monopoly. I prefer the classics: regular and Klingon.
Howard: Actually, Indian Monopoly is just like regular. Except the money is in rupees and instead of hotels, you build call centers. And when you pick a chance card, you might die of dysentery. Just FYI, that was racist.

Sheldon: Ah, memory impairment; the free prize at the bottom of every vodka bottle.

Leonard: Would someone please turn off the Sheldon commentary track?

Zack: You're inferring I'm stupid.
Sheldon: That's not correct. We implied you're stupid, you then inferred it.

Sheldon: Here's an interesting fact about alcohol: Man is not the only species that ferments fruit in order to become intoxicated. Can you guess what the other is? Hint: sometimes they pack the alcohol in their trunks.
Penny: Monkeys.
Sheldon: When does a monkey have a trunk?
Penny: When a suitcase just won't do.

Sheldon: Mmm, this is good. Whatever this is.

Penny: You know Amy, when we say we're having girl talk, it doesn't mean that we just have to talk about our ladyparts.
Amy: That's a shame. I had a real zinger about my tilted uterus.

Sheldon: 'He drank from Leonard`s glass' - the words they will be carving into my tombstone.

Penny: Are you saying that Amy is, oh, what's the scientific word-
Sheldon: Forget science: she's horny.

Penny: Sheldon, you can't re-program people.
Sheldon: No, you can't re-program people.

Zack: Wow, this place is awesome. Where do they keep the Archies?
Sheldon: In the bedrooms of ten-year-old girls, where they belong.
Zack: Oh, no, you're thinking old-school Archie. It's much more sophisticated now. Like, there's two universes, and Archie's married to Betty in one and Veronica in the other. Midge is even breaking up with Moose.
Raj: No.
Zack: About time, right?
Stuart: Hey.
Zack: Hey.
Stuart: You guys finally chip in for a bodyguard?
Leonard: Uh, no. Oh, this is Zack. He's a friend of ours. Zack, this is Stuart. He owns the store.
Zack: Wow, lucky you.
Stuart: Yeah, I work 70 hours a week and average a dollar sixty five an hour.
Zack: Sweet.
Stuart: Is that sarcasm?
Howard: Uh, no, it's an indictment of the American education system.
Raj: The Archies are over here.
Zack: Yippee.

Sheldon: Are you suggesting I play dirty?
Amy: Yes, dirty. Dirty, dirty, dirty. Which brings me to our next order of business. [kisses Sheldon]
Sheldon: Fascinating.
Amy: I hope you don't take what I'm about to do as a comment on what we just did. [runs to bathroom and vomits]

Howard: Oh great it's my cousin David about the ring. Hey David what'd you find? Sure half a carat is fine. Her freakishly small hands make anything look big. It's one of the reasons I love her.

Wolowitz: You got her to have sex with you. Obviously your super power is brainwashing.

Howard: Women, you can't live with them. You can't successfully refute their hypotheses.
Sheldon: Amen to that.