Howard: That doesn't count. Do over! Do over!
Sheldon: There are no do-overs in Wii bowling.
Howard: There are always do-overs when my people play sports.

Raj: Whoa. Humongous man crush, dude.

Howard: Yep. It's officially a bro-mance.

Dave: I don't know how you live next door to that without doing something about it.
Leonard: Actually, science is my lady.

Sheldon: What it is is a cacophonous assault of eucalyptus, bayberry, cinnamon and vanilla. It's as if my head were trapped in the pajamas of a sultan.

Leonard: I've been offering to show you around for a year and a half. You always said you had yoga.
Penny: I never said that.
Leonard: Maybe I heard you wrong. A lot of words sound like yoga.

Penny: Dave is not smarter than you. He's an idiot.
Leonard: Really? Why would you say that?
Penny: Because a smart guy takes the nude photos of his wife off his cell phone before he tries to take nude photos of his girlfriend.
Leonard: He tried to take nude photos of you?
Penny: That's what you took from that? The guy is married.

Leonard: Oh, a gift certificate for motorcycle lessons. Very thoughtful.
Penny: Yeah, and I checked. Not letting the bike fall on you while standing still is lesson one.

Leonard: Oh, then I think you'll appreciate what I got you.
Penny: Okay. 101 Totally Cool Science Experiments for Kids.
Leonard: You know, 'cause you're so into science.

Stephanie: I don't see anything at all, Sheldon.
Sheldon: Well, you're the doctor, but I am constantly hearing this annoying sound.
Leonard: Me too.
Sheldon: Is it a high frequency whistle?
Leonard: No, it's more of a relentless, narcissistic drone.

Leonard: No, absolutely not.
Sheldon: It's not a big deal.We have latex gloves.
Leonard: I don't care what the symptoms are. My girlfriend is not going to give you a prostate exam.

Leonard: Don't you think if a woman was living with me I'd be the first one to know about it?
Penny: Oh, sweetie, you'd be the last one to know about it.

Sheldon: I trust Leonard satisfied you sexually last night.
Leonard: Oh good God! Sheldon we don't ask questions like that!
Sheldon: I heard you ask it over and over. How is it inappropriate for me to ask it once?
Stephanie: He did very nicely.
Sheldon: See? She's not offended. And now you finally have an answer.

Sheldon's computer: We are out of herbal tea. Do you have any?
Penny: Okay, let me check.
Sheldon's computer: Some hiney would be nice.
Penny: Hiney?
Sheldon's computer: Honey.

Stephanie: Where did you get the stethoscope and the blood pressure cuff?
Sheldon: My aunt Marion gave them to me for my 12th birthday. She thought if I failed at theoretical physics that I should have a trade to fall back on.