Bill Nye: What are you guys working on?
Leonard: We're making nano-vacuum tubes.
Bill Nye: Interesting.
Professor Proton: Haven't you stolen enough from? Back off bow-tie!

Professor Proton: Sheldon, what are you doing here?
Sheldon: I'm sorry, did I wake you?
Professor Proton: Of course you woke me, it's seven thirty.

Sheldon: I would have been here sooner but for some reason your home isn't on this map of Hollywood stars.

Professor Proton: What do you want, Sheldon?
Sheldon: It's been pointed out by my girlfriend that I may have been annoying to you.
Professor Proton: She sounds like a keeper.

Professor Proton: Sheldon, in a couple of hours I have to get up, pee and then wander around the house.

Sheldon: Now that you and I are friends again, I am at your disposal. And frankly, lending my name and reputation to it will help. Because a lot of people think you're a washed up has-been ... or dead.
Professor Proton: I should be so lucky.

Sheldon: And to think I idolized that man. And why? At the end of the day, he's just another Hollywood phoney.
Amy: Is it really worth getting upset about?
Sheldon: They say don't meet your heroes. Don't peek behind that curtain of fame and celebrity. Because if you do, you'll see them as they really are: degenerate carnival folk.

Amy: Come on, he's a retired kids show host.
Sheldon: That's even worse. Using the sweet candy of science to trick children into loving him. ... Pervert.

Amy: Have you ever wondered why Arthur didn't want you to read his paper?
Sheldon: Yes, I have. And my only conclusion is the prescription he was picking up the other day was for cuckoo pills.

Amy: This is fun. I'm gonna feel like a vixen wearing jewellery that doesn't have a list of medications I'm allergic to.

Amy: How do you not know how to use glue? Did you ditch pre-school?
Penny: Yeah, but only because I was dating a second-grader.

Leonard: Dr. Jeffries, hello again. Leonard Hofstadter.
Professor Proton: Oh, right. I remember your girlfriend. *Looking around* Is she here?

Sheldon: So what prescription are you getting filled?
Leonard: Sheldon!
Sheldon: No wait, I want to guess. Don't tell me.
Professor Proton: I wasn't going to tell you.

Sheldon: No, wait. I'm really good at this. Give me a hint. Does it involve difficulty initiating a stream of anything?
Professor Proton: Well, given my age, that's more than just a lucky guess.

Raj: Excuse me, I happen to be very comfortable with my masculinity.
Howard: How is that possible?