Howard: It's a small, brown paper bag, ma, I'm looking at it right now. Why would I make that up? There's no Ding Dong in it. How are two Ding Dongs tomorrow gonna help me today?

Leonard: You guys ready?
Raj: In a minute. Howard stepped outside to throw up.

Dr. Koothrappali: Tilt up the camera, I'm looking at his crotch.
Raj: Sorry, Papa!
Dr. Koothrappali: Oh, there's much better. Hi.

Sheldon: (Knocking) Leonard? Leonard? Leonard?
Leonard: Let it go, Sheldon. The murderer was the first mate whether it made sense to you or not.

Howard: I don't know, Sheldon, those topical conferences on Bowes-Einstein condensates parties are legendary.
Leonard: Forget the parties.
Howard: Forget the parties!? What a nerd!

Rajesh: Why don't we do it your way then? We'll arrange for this girl to move in across the hall from Dennis so he can pathetically moon over her for months on end.
Leonard: Okay, that was uncalled for.
Rajesh: You started it, dude.

Sheldon: I am truly sorry for what happened last night. I take full responsibility. And I hope that it won't color your opinion of Leonard, who is not only a wonderful guy, but also, I hear, a gentle and thorough lover. (Penny slams the door in Sheldon's face)

Howard: Alright, just a few more feet, and ... here we are gentlemen, the Gates of Elzebob.
Sheldon: Good lord!
Raj: Oooh.
Leonard: Don't panic, this is what the last 97 hours have been about.

Howard: Stay frosty, there's a horde of armed goblins on the other side of that gate guarding the Sword of Azeroth.
Leonard: Warriors, unsheathe your weapons, magic wielders raise your wands.
Sheldon: Lock and load.
Howard: Raj, blow up the gates.
Raj: Blowing the gates. Control, shift, B! Oh, my God, so many goblins!

Leonard: I just, I got your mail again, here.
Penny: Thank you. I've got to talk to that mailman.
Leonard: Oh no, that's probably not such a good idea. Civil servants have a documented propensity to, you know, snap.

Sheldon: I have noticed that Lesley Winkle recently started shaving her legs. Now, given that winter is coming one can only assume that she is signaling sexual availability.

Leslie Winkle: What do you think?
Leonard: You proposed the experiment, I think you should present your findings first.
Leslie Winkle: Fair enough. On the plus side, it was a good kiss, reasonable technique, no extraneous spittle. On the other hand, no arousal.
Leonard: None?
Leslie Winkle: None.
Leonard: Ah. Well, thank you for your time.
Leslie Winkle: Thank you.

Leonard: God, that's a good song.
Sheldon: If you're compiling a mix CD for a double suicide.

Sheldon: Oh, I hope that scratching post is for you.
Leonard: I know what you're thinking. I've taken your asthma into account. There's a feline geneticist in San Diego who has developed the cutest little hypo-allergenic calicos.
Sheldon: Leonard, listen to me.
Leonard: I've been thinking about names. I'm kind of torn between Einstein, Newton and Sergeant Fuzzyboots.

Sheldon: What time is your date?
Leonard: Six thirty.
Sheldon: Perfect, that gives you two hours and fifteen minutes for that dense molecular cloud of Aramis to dissipate.
Leonard: Is it too much?
Sheldon: Not if you're a rugby team.