Sheldon: Howard, you're feeling better about me today, aren't you?
Howard: Not really.
Sheldon: Yes, you are. I'm using neurolinguistic programming to modify your thought patterns.
Howard: Oh. Go away, Sheldon.
Sheldon: There's a nine-ninety-five e-book down the drain.

Leonard: Remember when you were wondering why the girls didn't want to eat with us tonight?
Howard: Yeah, I get it now.

Penny: He just didn't really challenge me on an intellectual level.
Bernadette: Couldn't you just fool around with him and then listen to NPR?
Penny: Wouldn't help. Zack couldn't even spell NPR.

Howard: First of all, if we had superpowers, I wouldn't be the sidekick. You'd be the sidekick.
Raj: Rat-Man is nobody's sidekick.

Sheldon: What were the symptoms?
Amy: Elevated heart rate, moist palms, dry mouth and localized vascular throbbing.
Sheldon: Localized to what region?
Amy: Ears and genitalia.
Sheldon: Interesting. Not body parts that usually team up.

Howard: Let me ask you a question. What are you afraid of?
Raj: I don't know. Um, nuclear war. Accidentally being buried alive. Any of those movies where you get that phone call that says you're going to die, and then you do.
Howard: No. Something very specific that we both know you, Rajesh Koothrappali, are terrified of.
Raj: Well, type two diabetes runs in my family. The thought of losing a toe-
Howard: Spiders! You're afraid of spiders.

Sheldon: How about your follicle-stimulating hormone levels?
Amy: Sheldon, I am not going through menopause.
Sheldon: Are you sure? You said that with the testy bark of an old biddy.

Leonard: I suppose there are worse ways to spend a Friday night. None come to mind.

Amy: Excuse me, Zack? I am Amy Farrah Fowler. We met the other night. I have spent my life in pursuit of pure knowledge. Until I met you, my decisions were founded in logic and reason. And yet here I stand before you, one hundred and thirty pounds of raging estrogen, longing to grab hold of your gluteus maximus and make Shakespeare's metaphorical beast with two backs.
Zack: My gluteus what?
Amy: On the other hand, as I look at the blank, ape-like expression on your face, I have decided to adopt the Vulcan practice of Kolinar. Goodbye, Zack.

Leonard: You think Penny's right? Were we bullying Zack?
Howard: No, I know bullying. He left here unswirlied and his ass crack was underpants-free.
Raj: And nobody drew a penis on his forehead.
Leonard: That happened to you?
Raj: First day of cricket camp. They drew it so the testicles were my eyes.

Howard: A few extra bucks would be nice. I could finally move out of my mother's house.
Raj: Where would you go?
Howard: I always dreamed about building a little place of my own over the garage.

Sheldon: She befriends them and then lies in wait until they reveal a marketable idea, which she steals and sells to the highest bidder.
Leonard: That's ridiculous.
Sheldon: Oh, is it? Well, let's see you come up with an explanation as to why this woman hangs out with us all the time.
Penny: Oh, great. You know what? I've already mooched dinner off you guys. I don't need to listen to this.
Howard: There's your answer: free food.

Raj: Hey, why am I in charge of phone support? Seems a bit racist.
Sheldon: A customer service representative with an Indian accent will create the impression that we're a vast enterprise that uses overseas call centers.
Raj: Oh, very clever. But still racist.
Sheldon: Duly noted, Steve from Wichita.

Howard: Why am I listed as your executive assistant?
Sheldon: Because the word secretary has fallen into disrepute. FYI, my mother's birthday is coming up. I'm going to need you to pick up a present.

Sheldon: Look at the organizational chart. You're clearly listed as founder.
Leonard: Well, yes, and you're listed as Chief Executive Officer, Chief Financial Officer and Chief Operating Officer.
Sheldon: You missed Chief Science Officer, Chairman of the Board, and Head of the Secret Santa Committee.