Howard: Okay. Okay, I know you're upset, but let me share something I've learned since I got here. You realize how small your problems are when you're looking down on them from space. Now, come on, that's got to make you feel better.
Bernadette: How clear is the image of me on that screen?
Howard: Pretty clear.
Bernadette: Do I look like I feel better?
Howard: I mean, it's not, like, HD quality.

Bernadette: Listen, mister, you're gonna talk to your mother and you're gonna fix this, or that thing I said I was gonna do to you the minute you got home, you can do to yourself.
Dimitri: Like he's been doing since he got here.

Amy: Sheldon, this place is so romantic.
Sheldon: Oh, I'm glad you like it. Raj picked it out.
Amy: Well, when you see him, tell him I say thank you.
Sheldon: Tell him yourself.
Raj: Yoo-hoo! Over here!

Stuart: So, Howard's really in space, huh?
Leonard: Mmm-hmm. International Space Station. 250 miles that way.
Raj: Right now, Howard's staring down at our planet like a tiny Jewish Greek god. Zeusowitz.

Sheldon: I must admit, I can't help but feel a twinge of envy. He can look out the window and see the majesty of the universe unfolding before his eyes. His dim, uncomprehending eyes. It's like a cat in an airport carrying case.

Leonard: You know, it's not exactly glamorous up there. The water that the astronauts drink is made from each other's recycled urine.
Stuart: Must be nice. Nobody wants anything that comes out of me.

Penny: Just a couple of minutes. You've really never done this before?
Amy: Once in high school, but I dozed off and woke up with second-degree chemical burns on my face.
Penny: Oh, my gosh, that's awful. The other kids make fun of you?
Amy: No, I had a cover story, I told everyone it was herpes.

Sheldon: Raj, where do you stand on the anthropic principle?
Raj: I'm all for it.
Sheldon: Attaboy.
Leonard: Well, hang on. Why do you believe that he knows what it is and I don't?
Sheldon: Oh, Leonard. Let's not take a saw to the branch we're sitting on, shall we?

Penny: I have no reason to ... "B" mad at you. Minus.
Leonard: Wow.
Penny: That's right. On my paper. Not yours, mine, you punk-ass elf.

Sheldon: Hello, I'm Dr. Sheldon Cooper. Welcome to Sheldon Cooper presents Fun with Flags. My apologies that this episode is coming late. I did shoot one last week in honor of Black History month, but I was informed by my roommate that my spot-on portrayal of George Washington Carver could be considered "wildly racist".

Howard: So, how have you been?
Mike Rostenkowski: Fine.
Howard: Good. Fine is good. How you liking retirement?
Mike Rostenkowski: It's fine.
Howard: I'm sensing a theme.

Mike Rostenkowski: Hold up. Bless us, O Lord for these Thy gifts which we are about to receive from Thy bounty through Christ our Lord. Amen.
Howard: Took the words right out of my mouth.

Mike Rostenkowski: That's what you're wearing?
Howard: No good? The guy at the sporting goods store said these are what fishermen wear.
Mike Rostenkowski: Maybe in cartoons.

Mike Rostenkowski: So, why'd you agree to come?
Howard: 'Cause Bernadette made me.
Mike Rostenkowski: I tried to back out, too. My wife said I had to go.
Howard: Really? Your wife makes you do stuff? You're a big, scary cop.
Mike Rostenkowski: You're an astronaut, and your wife makes you do things, and she's only four feet tall.

Raj: I have a thick accent. You don't know what I said.