Howard: Great, I'll do that when I want to be the first guy in space to get a wedgie.
Bernadette: Do you want me to call somebody at NASA?
Howard: No. My mom already tried that. It only made things worse.

Raj: Focused Locust.
Stuart: Temple of Yip.
Sheldon: I'm sorry. Wolowitz would never play that card.
Stuart: All right, Lesser Demon Turtle.
Sheldon: Fairy God Monster, I win. Your desperate need for friendship makes you weak.

Raj: So, what are you guys doing later? Stuart and I were thinking of going out for a drink.
Stuart: We're gonna try to meet some girls.
Raj: 'cause that's what we do.
Stuart: Watch out, ladies, a little coffee and cream coming your way.
Raj: In case you didn't follow that, I'm the coffee.

Sheldon: Do you remember how upset I was when they replaced Edward Norton as the Hulk?
Leonard: Yes, you walked around for a week saying, Sheldon unhappy with casting choice.
Sheldon: But, then Mark Ruffalo was the Hulk in The Avengers, and he was even better.
Leonard: What's your point?
Sheldon: Call me a romantic. I like to think that your Mark Ruffalo is still out there somewhere.

Penny: Look, it's fine. We're not getting married, okay? We're keeping things, you know, homeostasis.
Amy: It's so cute when she tries.

Leonard: I know what the anthropic principle is.
Sheldon: Of course. I just explained it to you. Now, where do you stand on it?
Leonard: Where do you stand on it?
Sheldon: Strongly pro.
Leonard: Then I believe that God created the world in six days and on the seventh he made you to annoy me.

Amy: If Sheldon proposed to me during sex, my ovaries would grab onto him and never let go.

Sheldon: Amy, when I look in your eyes and you're looking back in mine, everything feels not quite normal. Because I feel stronger and weaker at the same time. I feel excited and, at the same time, terrified. The truth is, I don't know what I feel, except I know what kind of man I want to be.
Amy: Sheldon, that was beautiful.
Sheldon: I should hope so, that's from the first Spider-Man movie.
Amy: I'll take it.

Dimitri: What are you gonna do when you get back to Earth?
Wolowitz: Oh, I'm never going back.

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Mrs. Wolowitz: Wives don't take boys from their mothers.

Penny: So, does Sheldon have anything special planned for you tomorrow night?
Amy: Oh, yes. According to the relationship agreement, on the anniversary of our first date, he must take me to a nice dinner, ask about my day, and engage in casual physical contact that a disinterested onlooker might mistake for intimacy.
Penny: That's hot. You kids better use protection.

Amy: I can't believe I bleached my moustache for this.

Raj: Waiter? A bottle of champagne and three glasses. Oh boy, isn't this romantic?
Sheldon: Oh, I hope that's a rhetorical question, because I have no clue.

Leonard: I got all your favorites. Beer, wings, sliders. We can watch the football game. I even painted my stomach.
Penny: Go Sports?
Leonard: Well, in case you were in the mood for baseball, I didn't want to look ridiculous.