Howard: Hey, she's my wife. If anyone's gonna make her feel gross about sex, it's me.

Sheldon: Oh, I'm fine. It's just some stomach medication for my trip. There's a remote yet distinct possibility that I may end up in South America.
Penny: Remember the old days when I would have said something dumb like "Why?"

Amy: Then I met Sheldon and look at where we are now.
Raj: You've kissed like once in three years.
Amy: That's true. Do whatever you want.

Bernadette: Raj, your tag's sticking out. *Bernadette tucks Raj's clothing tag back in*
Raj: Thank you. That's the closest I've come to sex in like two years.
Bernadette: Now I feel a little gross.
Raj: You're only making it seem more real for me.

Raj: Emily, your face is like a precious Dew-kissed flower.
Amy: Wow.
Raj: I know. Powerful stuff, huh?
Amy: No. You're supposed to be yourself. Not all desperate and creepy.
Raj: Okay, I'm getting some mixed messages here.

Amy: Before I met Sheldon I was ready to give up too. Once, I even called in on my OBGYN just for some human contact.
Raj: It has been a while since I got my prostate checked.

Raj: Not my best first date, but not my worst either.

Sheldon: Oh apple juice stay where you are.

Bernadette: You excited for Texas?
Sheldon: Oh, very much so.
Howard: It's not everyday you get to tour NASA with a real astronaut.
Sheldon: Ohh, who's the real astronaut?
Howard: ... Buzz Aldrin.
Sheldon: Oh, yay!

In-flight Announcement: The Captain has turned off the fasten seatbelt sign. You're now free to move about the cabin.
Howard: It's over.
Sheldon: Yeah.
Howard: Should we stop holding hands now?
Sheldon: In a minute.
Howard: Okay, good.

Raj: Hello, Emily.
Emily: Hello.
Raj: Amy told me you were concerned that I might be too passive and shy. Let me ask you something: would a passive guy barge in here to look you in the eye and say "Hey, dew-kissed flower. What's up?".
Emily: No, but a weird guy with no boundaries might.
Raj: Okay, that's a separate issue. Let's put a pin that and just focus on the passive thing.

Howard: I'm an astronaut and you know it. You just don't like admitting it because you're jealous.
Sheldon: Well, truth be told, as a child I did dream of going to space. Those astronauts were my heroes. And when you got to go, it was hard for me.
Howard: Thank you.
Sheldon: Because it made me realize they'll just send anyone up there.

Raj: I give you one simple thing to do: contact a complete stranger and make her fall in love with me, and you blow it!

Sheldon: I'm sorry for every mean thing I ever did or said to you.
Howard: I'm sorry too. It's all my fault.
Sheldon: If you weren't my friend there'd be a hole in my life.
Howard: Thank you, Sheldon.
Sheldon: Kind of like when Firefly was cancelled, but not as big.

Penny: Come on, let's just get this over with.
Leonard: "Let's just get this over with?" Am I driving you to the Cheesecake Factory or are we having sex?