Sheldon: I let you buy feminine hygiene products with my supermarket clubcard. Do you have any idea the kind of coupons I'm going to get in the mail now?

Sheldon: You hit me. I'm bleeding.

Leonard: Sheldon, this date is probably my one chance with Penny. What happens if I blow it?
Sheldon: Well, if we accept your premise, and also accept the highly improbable assumption that Penny is the only woman in the world for you, then we can logically conclude that the result of blowing it would be that you end up a lonely, bitter old man with no progeny. The image of any number of evil lighthouse keepers from Scooby-Doo cartoons comes to mind.

Howard: How's the air matress?
Sheldon: It's okay, if you don't mind sleeping on a bouncy castle.

Leonard: What's going on?
Sheldon: We scored. I'm the wingman.

Sheldon: I don't understand your objection, Professor Goldfarb. Why wouldn't the Sonora Desert make a perfectly good Promised Land?
Goldfarb: Go away!
Sheldon: We could call it Nuevo Jerusalem.
Goldfarb: Please go away!
Sheldon: Said Pharaoh to Moses!

Girl: What are you?
Sheldon: I'm gonna give you a hand: weawww.
Girl: A Choo choo train?
Sheldon: Close! weawwww
Girl: A brain damaged choo choo train?

Sheldon: Why would I feel safer with Zachary Quinto at the foot of my bed?
Leonard: I don't know, he was pretty bad ass on Heroes.
Sheldon: Nope. Sorry Quinto, you're going back!

Leonard: Hey, Raj, I read a couple guys in your department may have discovered a new planet in our solar system?
Sheldon: Oh, I heard about that. Why didn't you discover it?
Raj: Because instead of being in the telescope room, I was busy making you guys homemade jam for the holidays.
Sheldon: Well, you be sure to let us know when you win the Nobel Prize for boysenberry

Sheldon: Thank you, Arthur. You are the wisest of the wise.
Professor Proton: Well, that's very nice of you to say, but I think I'm just an expression of your unconscious mind.
Sheldon: Oh, sure. Well, you're fun to look at.

Penny: Okay, while they get the cake, Sheldon, I just want to say, I hope you didn't think you were gonna get through tonight without a hug.
Sheldon: You know, I used to hate these hugs. Now they're just extremely irritating.

Leonard: I still don't understand why you bought that pill caddie. You're a young man.
Sheldon: Age is a state of mind, Leonard. In here I'm 90.

Penny: Sheldon, please, we already feel bad about this.
Sheldon: You know what they don't sell at The Container Store? Something large enough to contain my disappointment.
Although, if anyone did, it would be them.

Sheldon: People should take care of themselves.
Leonard: Oh, like yesterday when you made me drive you to the dry cleaners, the pharmacy and the post office?
Sheldon: I'm not saying people can't use tools. Even an otter picks up a rock when he wants a clam.

Sheldon: How can we ever hope to have a healthy relationship if I don't tell her how disappointed I am and how I'll never forgive her.