Quote from the episode The Prestidigitation Approximation
Rajesh: Why so glum, chum?
Sheldon: Apparently you can't hack into a government supercomputer and then try to buy uranium without the Department of Homeland Security tattling to your mother.
Quote from the episode The Big Bran Hypothesis
Sheldon: Oh Gravity, thou art a heartless b*tch.
Quote from the episode The Thespian Catalyst
Penny: Mrs Cooper? Hey, it's Penny. I think I broke your son. Hold on. (To Sheldon) Talk to your mother.
Sheldon: (Crying) Mummy, I love you. Don't let Spock take me to the future!
Quote from the episode The Flaming Spittoon Acquisition
Sheldon: I believe I would like to alter the paradigm of our relationship.
Amy: I'm listening.
Sheldon: With the understanding that nothing changes what so ever - physical or otherwise, I would not object to us no longer characterizing you as not my girlfriend.
Amy: Interesting, now try it without the quadruple negative.
Quote from the episode The Lunar Excitation
Zack: Is that the laser? It's bitchin'.
Sheldon: Yes. In 1917, when Albert Einstein established the theoretic foundation for the laser in his paper "Zur Quantentheorie de Strahlung", his fondest hope was that the resultant device be bitchin'.
Quote from the episode The Robotic Manipulation
Sheldon: I am aware of the way humans usually reproduce which is messy, unsanitary and based on living next to you for three years, involves loud and unnecessary appeals to a deity.
Penny: Oh, God.
Sheldon: Yes, exactly.
Quote from the episode The Bat Jar Conjecture
Howard: Don't you think I should answer the engineering questions? I am an engineer.
Sheldon: By that logic I should answer all the anthropology questions because I'm a mammal.
Quote from the episode The Agreement Dissection
Sheldon: (To Priya) You may have gone to Cambridge but I'm an honorary graduate of Starfleet Academy!
Quote from the episode The Vegas Renormalization
Sheldon: There was a tall man from Cornwall
Whose length exceeded his bed.
"My body fits on it
But barely upon it
There's no room for my big Cornish head!"
Quote from the episode The Boyfriend Complexity
Sheldon: Einstein defined insanity as doing the same thing over and over again and expecting different results. By that definition, Penny is cuckoo for Cocoa Puffs.
Quote from the episode The Desperation Emanation
*Sheldon spots Amy Farrah Fowler outside the apartment*
Sheldon: Oh dear... they really do be crazy.
Quote from the episode The Roommate Transmogrification
Sheldon: Here's an interesting fact about alcohol: Man is not the only species that ferments fruit in order to become intoxicated. Can you guess what the other is? Hint: sometimes they pack the alcohol in their trunks.
Penny: Monkeys.
Sheldon: When does a monkey have a trunk?
Penny: When a suitcase just won't do.
Quote from the episode The Adhesive Duck Deficiency
Sheldon: There there, everything is going to be fine... Sheldon's here!
Quote from the episode The Justice League Recombination
Zack: You're inferring I'm stupid.
Sheldon: That's not correct. We implied you're stupid, you then inferred it.
Quote from the episode The Flaming Spittoon Acquisition
Penny: Strap on a pair and go talk to Amy.
Sheldon: Strap on a pair of what ... skates?
Penny: Oh, you are so not the guy.
Quote from the episode The Wheaton Recurrence
*After getting a spare in the bowling match*
Sheldon: THANK YOU JESUS!!! ... as my mother would say.
Quote from the episode The Zazzy Substitution
Sheldon: I know mother, but you're not fooling me. Every time you want to talk it means you want me listen.
Mrs. Cooper: Then stop talking.
Sheldon: Yes, M'am
Quote from the episode The Terminator Decoupling
Sheldon: She calls me moon-pie because I'm nummy-nummy and she could eat me up!
Quote from the episode The Electric Can Opener Fluctuation
Sheldon (to his mom): But, evolution is not opinion, it's a fact!
Sheldon's mom: And that is your opinion!
Sheldon (to Leonard, Howard and Raj): I forgive you, let's go home.
Quote from the episode The Gothowitz Deviation
Leonard: Sheldon, you can't train my girlfriend like a lab rat!
Sheldon: Actually, it turns out I can.
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