Amy: Do you think it's possible you might enjoy being on your own for a little while?
Sheldon: It's hard to say. I've never really lived by myself. What if I become strange and eccentric?
Amy: I'll love you no matter what.
Sheldon: Howard Hughes saved his urine in milk bottles.
Amy: We'll cross that bridge when we come to it.

Amy: I don't know, maybe I shouldn't go.
Penny: Oh, stop it, he'll be fine.
Amy: I guess. And he'll have you and Leonard right across the hall the whole time.
Penny: Oh, damn, wait, you know, maybe you shouldn't go-
Amy: Got to go! (Hangs up the phone)

Bernadette: You're still gonna go, right?
Amy: I don't know. Sheldon's so vulnerable right now.
Penny: Oh, come on. Look, if the roles were reversed, he'd be on the first train to New Jersey. Or the second train if there were teenagers on the first one.

Bernadette: So what happens next?
Howard: Phase two: we test it, perfect it, and hope to live long enough to see the movie based on our lives starring more attractive versions of us.

Howard: I mean, an entire year wasted.
Bernadette: You might be forgetting another accomplishment of the past year.
Howard: Oh. Yeah, yeah, we brought life into the world.
Bernadette: Really? That's the importance you put on us having a baby?
Howard: I'm happy about it, but, I mean, it's not like I did much. I mean, after the first three minutes it was pretty much all you.

Sheldon: I feel so betrayed. You know, all my life I thought Uncle Sam was a friendly uncle who brought you presents. Turns out he's the other kind.

Raj: Bert has a room for rent.
Bernadette: So you're gonna be roommates with Bert?
Raj: Uh, no, it's, uh, pretty private, actually, it's over his garage. So the only time I'll see him is when he pulls his car in, does his laundry or practices drums in my dining room.

Penny: So, did you tell him about Princeton yet?
Amy: No, I'm waiting till he's in a good mood.
Penny: Oh, sweetie, you might not live that long.

Sheldon: Uh, I know it's not your birthday, but if you're interested-
Amy: I am.
Sheldon: Okay. Oh, and just to be clear, I'm not being intimate with you in order to keep you from going.
Amy: I wasn't thinking that.
Sheldon: Well, no, it's just, I'm just warning you, you know, if you find yourself 3,000 miles away and craving a hit of this, you know I can't Skype it to you.
Amy: That's a risk I'm willing to take.
Sheldon: All right, then.

Sheldon: And don't forget to Skype me when you arrive.
Amy: I won't.
Sheldon: And every morning.
Amy: Got it.
Sheldon: Now of course, my 9:00 a.m. is your noon, so let's avoid the whole "good morning," "good afternoon" minefield, and let's just say, "Hello."
Amy: Good thinking.

Bernadette: I don't know if you realize this, but whenever you're between projects, you tend to get a little insecure.
Howard: Oh.
Bernadette: A little clingy.
Howard: I know and I'm sorry. (starts kissing her)
Bernadette: Oh, oh, oh, okay, stop. Stop. I love when you're affectionate, but this is not coming from a good place.
Howard: (laughing) Well, excuse me, but what did you do when you worked on that allergy drug for two years and the FDA shut down your project?
Bernadette: I signed us up for ballroom dance class.
Howard: Okay, and what did you do when they took you off the anti-fungal team?
Bernadette: I made us have a baby.

Bernadette: Well, distance might be nice. The last time a big project ended for Howie, he wouldn't stop following me around. He even went with me to get a mammogram.
Penny: Well, what's wrong with that?
Bernadette: No, he wanted to get one with me, like some kind of weird couple's massage.
Penny: And yet you bore his child. Neato.

Leonard: First thing tomorrow morning, we're back at it.
Raj: Without me.
Sheldon: I hope his character doesn't make it into the movie; he's kind of a bummer.

Amy: You know, what you need to do is put this Air Force project behind you and just dive into something new.
Sheldon: Well, there is our quantum cognition experiment. You and I could spend more time on that.
Amy: Oh, I don't know, I mean, let's say we succeed in proving that our consciousness creates reality.
I mean, what will we have really accomplished? You know, a loaf of bread's still three bucks.

Amy: I made your favorite oatmeal - plain.