Sheldon: Given that Saint Valentine was a 3rd century Roman priest who was stoned and beheaded, wouldn't a more appropriate celebration of the evening be taking one's steady gal to witness a brutal murder?

Raj: Okay, show of hands: who's up for this?
(Howard eagerly raises his hand)
Leonard: We'll all be naked, in front of each other.
Howard (lowering his hand): I'm out.

Sheldon: That does smell good, too bad it's Monday.

Raj: I don't wanna sit by myself.
Sheldon: That's what Typhoid Mary said and clearly, her friends buckled.

Sheldon: Have you suffered a recent blow to the head?
Penny: Hey, you don't have to be so mean.
Sheldon: Oh, I'm sorry, (smiling) have you suffered a recent blow to the head?

Leonard: What am I supposed to ask her? "Hey Penny, you got any friends that you never want to talk to again?"

Penny: When I was a senior in high school, one of my friends heard I was gonna be named head cheerleader, I was so excited. My mom even made me a celebration pie. Then they named stupid Valerie Mossbacher head cheerleader, big old slutbag.
Sheldon: Are you saying that you think a celebration pie is even remotely comparable to a Nobel Prize?
Penny: Well, they're pretty tasty.
Sheldon: And on a different, but not unrelated topic, based on your current efforts to buoy my spirits, do you ever truly believe that you were fit to be a cheer leader?

Sheldon: Where are my pants?
Leonard: You might wanna check out YouTube.

Sheldon: When do you evacuate your bowels?
Leonard: When I have to.
Sheldon: When you have to? I'm sorry I don't rent to hippies.

Raj: These methods of meditation come from the ancient gurus of India, and have helped me overcome my own fears.
Sheldon: And yet, you can't speak to women.
Raj: True, but thanks to it I am able to stay in the same room with them without urinating.

Sheldon: According to the inexplicably irritable nurse behind the desk, you'll be seen after the man who claims to be having a heart attack, but appears to be well enough to play Doodle Jump on his iPhone.

Sheldon: Hello, I know you're out there. I can hear you metabolizing oxygen and expelling carbon dioxide.

Leonard: Sheldon, you need to find a better way of dealing with Penny.
Sheldon: What am I supposed to do? Eat French Toast on a Monday? Now that would be impossible.

Sheldon: On the contrary I find the Grinch to be a relatable and engaging character. And I was really with him, right up to the point that he succumbed to social convention, returned the presents and saved Christmas.

Raj: You always do this, you know, ditch me for a woman you don't have a shot with.
Howard: I totally had a shot.
Raj: With a woman you were chasing in a park. That's not a shot, that's a felony.