Sheldon: Oh, Penny, excellent. I have a question about these maxi pads. Are the wings truly functional or have I fallen victim to marketing hype?
Penny: What? What are you doing with, what?
Sheldon: The stock boy at Walgreens was frustratingly uninformed on the subject.

Penny: Sheldon, what are you doing with maxi pads?
Sheldon: I have a lady friend who will be staying with me for a few days.
Penny: Oh. What?
Sheldon: I want her to feel at home. I also bought scented soaps, pantyhose, Midol, calcium chews and what is apparently a yogurt specifically designed to regulate the female bowel.
Penny: Wait, wait, hold on, back up. You're having a woman stay with you?
Sheldon: Yes. Why does that seem to flabbergast everybody?
Penny: Oh, no, no, no, no. I'm not flabbergasted. I'm puzzled. Yeah, let's go with puzzled.

Leonard: Hi-lo. Oops. I started to say hi and then I switched to hello in the middle. It came out hi-lo. Duh. Uh, it's nice to meet you. I've read both your books and most of your papers. I'm Leonard, I live here. You're brilliant.
Sheldon: I apologize. He's only an experimental physicist.
Elizabeth: No need to apologize. Some of my best friends are experimental physicists. Well, not my best friends, but I know them. My best friend is a molecular chemist named Wendy. I'm sorry, I'm rambling. Hi-lo.

Leonard: (To Dr. Elizabeth Plimpton) I think any university would want you. Except, of course, any university that had already had you. Because they would've already wanted you before they, you know, got you.
Sheldon: From the mind that brought you hi-lo.

Sheldon: All right, let me show you some of the features of the room. First, windows. Conventional. Open, closed, open, closed. Halfway open or halfway closed, depending on your philosophical bent. Over here is my comic book collection. Feel free to browse. There's a box of disposable reading gloves on the night stand.

Dr. Elizabeth Plimpton: Can I ask a question about your roommate?
Sheldon: He's an odd duck, isn't he?
Dr. Elizabeth Plimpton: What's his relationship status?
Sheldon: Well, there was a misbegotten adventure with a waitress who lives across the hall. It ended as inexplicably as it began. They had very little in common, except for carnal activity. That's why I acquired these noise-canceling headphones. If you decide to use them, please clean the ear pieces afterwards with the Wet Wipes you'll find in the bathroom. They're in the drawer labeled Wet Wipes.

Sheldon: All right, Elizabeth, the bathroom is yours. The seat is down, and has been sanitized for your protection.
Dr. Elizabeth Plimpton: That's very thoughtful, but I think I'll finish my coffee first.
Sheldon: Ah, so the yogurt didn't work. I'll fire off a critical e-mail to the manufacturer.

Penny: You know what? I'm just gonna take the bus to work.
Leonard: Penny, I can still drive you.
Penny: Oh, no, no, it's okay. You might slip on a banana peel and get me pregnant.

Sheldon: I must say, I'm shocked by this betrayal.
Leonard: I didn't betray Penny.
Sheldon: Not Penny, me!
Leonard: How am I betraying you?
Sheldon: Elizabeth's my friend, and you're playing with her!
Leonard: Yeah, I guess I did.

Howard: What the hell are you doing?
Raj: Relax, it's Nyquil.
Leonard: You still have a cold?
Raj: Maybe, but I don't care. That's the great thing about Nyquil, it's like ten-percent booze. I call it the nighttime sniffling, sneezing, coughing, so you can talk to girls medicine.

Sheldon: Let me point out that two degrees can be the difference between water and steam.
Leonard: Yes, if we lived in a tea kettle.

Penny: So Sheldon's last roommate tried to warn you off?
Leonard: For all I knew, he was the crazy one. He had this really deranged look.
Penny: Well, yeah. He'd been living with Sheldon.

Sheldon: That's where I sit.
Leonard: What's the difference?
Sheldon: This seat is ideally located both in relation to the heat source in the winter and a cross breeze in the summer. It also faces the television at a direct angle allowing me to immerse myself in entertainment or game play without being subjected to conversation. As a result, I've placed it in a state of eternal dibs.

Leonard: I did notify you.
Sheldon: Oh, you did, did you? Oh, drat. Hoisted by my own spam filter.

Sheldon: Wait, let me get my jacket.
Howard: You're not going with us.
Sheldon: Why not?
Raj: You're the guy we're trying to get away from.
Sheldon: Oh. Well, in that case, I don't need my jacket. And for the record, the correct syntax is I'm the guy from whom you're trying to get away.