Howard: Look, I made Sheldon disappear. Ta-da.
Leonard: Next time, you should open with that.

Penny: So, are we celebrating anything special tonight?
Amy: Oh, yes. Our relationship agreement specifies that the second Thursday of every month, or the third Thursday in a month with five Thursdays, is date night.
Penny: That is so hot.

Sheldon: Ooh! Speaking of good news, somebody just hit 100 Twitter followers.
Amy: That's nice. Anyway, I've been dreaming of this day for a long time.
Sheldon: Yeah, me, too. Triple digits, I'm not gonna lie, feels pretty good.
Amy: Sheldon, I'm the sole author on a paper being published in a distinguished journal that may change the course of my field.
Sheldon: Mm-hmm. Mm-hmm. Ooh, 101! Air's getting a bit thin up here.

Penny: Okay, Amy just told you some exciting news, and you acted like it was no big deal.
Sheldon: Oh, I see why you're confused. No, her news sounded important, but what you're forgetting is, it was an achievement in the field of biology. That's all about yucky, squishy things.

Penny: Honey, she's upset. You're her boyfriend. You have to at least try to be excited by the things she's excited by.
Sheldon: What if they simply don't excite me?
Penny: Well, just smile and think about koalas.
Sheldon: She'd see right through that. We go to the zoo all the time. She knows my koala face. And for future reference, it's this.

Bernadette: Oh, you have a lot of magic stuff.
Howard: Yeah. I started when I was a teenager. I thought I could show a girl a few tricks and invite her up to my bedroom to see the rest of the act.
Bernadette: Did it work?
Howard: Ah, let's just say the only wand that ever saw any action was this one.

Leonard: Oh, a little Red Dead Redemption, huh?
Sheldon: Yes.
Leonard: How come you're not doing a mission? You're just wandering around.
Sheldon: Had a rough night. I thought I'd go for a walk and clear my head.
Leonard: Some people go outside and do that.
Sheldon: It's after nine o'clock, at this hour the streets of Pasadena are teeming with drunken sailors and alley cats.

Leonard: Glad I could help.
Sheldon: It's appreciated. And if you ever manage to find a woman again, I'll be glad to return the favor.

Penny: Ooh, does she like bracelets?
Sheldon: Well, she's very fond of her silver one that says allergic to penicillin. Maybe they have a dressier version of that?

Howard: I'm still trying to wrap my mind around it. I always thought I'd be a dad someday.
Raj: Oh, me, too. You're so caring. I've often pictured you guiding a young boy into manhood.
Leonard: There you go, Howard. Sounds like Raj'll have your babies, problem solved.

Raj: What's your mom going to say if you call off the wedding?
Howard: Huh, it'll kill her. On the other hand, if I don't give her grandchildren, that'll kill her, too. So, either way, on the Mom front, I'm golden.

Sheldon: What time did you tell Amy to be here?
Penny: Eight o'clock. (Sheldon checks his pocket watch) Sheldon, that pocket watch is ridiculous.
Sheldon: Nonsense. I look like a train conductor.

Sheldon: Under what pretext did you lure her here?
Penny: I said, hey, want to come over and hang out?
Sheldon: Good, good, if you had said something clever, she might've gotten suspicious.

Bernadette: Do you think you'll sleep with him tonight?
Penny: Absolutely not. Look, we're just gonna have dinner and, you know, see how it goes.
Amy: If he were dying, would you sleep with him?
Penny: What?
Amy: Assuming he were dying of something that couldn't be sexually transmitted. You know, like a spear wound to the head.
Penny: Okay, he is not dying.
Amy: How do you know? Are you a doctor?

Bernadette: You can make-believe, though. Sometimes Howard and I pretend that his arrhythmia is acting up and I'm a sexy cardiologist. And the naughty part is I'm not in his HMO network.