Leonard: I swear, that man is the most egotistical, insufferable human being I have ever met.
Penny: Yeah, but you two make such a cute couple. Like Bert and Ernie. You guys even teach me stuff about words and numbers.

Leonard: I don't know why I avoided the Harry Potter books for so long. These are great. I just started number six.
Sheldon: That's a good one. Dumbledore dies in that one. Yeah, I know, I didn't see it coming, either.
Leonard: Why would you say that?
Sheldon: You brought up the subject. I contributed an interesting fact on that subject. It's called the art of conversation. Okay, your turn.

Sheldon: It's Penny's fault.
Amy: What?
Sheldon: She doesn't want to live with Leonard, so he has to come live here again. She's the snake in our garden. She's the reason we can't be happy.

Sheldon: Hey, good buddy. So, uh, I was just talking to Amy, and she made me realize that this little dust-up between you and me is much ado about nothing.
Leonard: Is that so?
Sheldon: Yes. All is forgiven, so come back home. I'll make you some soy hot chocolate, and then I'll you tell you about our exciting new devil-may-care bathroom policy.

Raj: Dude, I'm a single man. Saturday night is my party night.
Howard: Really? What do you got going on?
Raj: I don't know. Maybe drive down to Hollywood, hit a few hot spots, see if I can get lucky.
Howard: Yeah, tell me if this sounds familiar. You pay fifteen dollars to park, you stand on the pavement for an hour until you break down and give the bouncer twenty bucks to let you in. You push your way to the bar, where you drink an eighteen dollar cosmopolitan, then you stare at a pretty girl and imagine your perfect life together. Your children, grandchildren. Meanwhile, she leaves with a guy who claims he wrote Beverly Hills Chihuahua. Then you give up on anyone ever loving you, go to Marie Callenders, buy a pie and eat it in your car in the parking lot.
Raj:What time should I be at your mother's?
Howard: I told her around seven.

Leonard: I'm not going anywhere. Penny and I are very happy living together. Isn't that right?
Penny: It's like the happiness won't ever leave the apartment.

Amy: Then what the hell, Sheldon? We have been going out for over two years, and I have been nothing but patient with you. I watch your dopey space movies. I signed your ridiculous contract. I even stopped wearing lip gloss 'cause you said it made my mouth look too slippery. I am the best girlfriend youre ever gonna have. You give me one good reason why I can't live here.

Howard: Great. Come on in.
Raj: What, you don't say thank you?
Howard: It's my suitcase. I lent it to you two years ago.
Raj: Well, then, I should tell you I broke the wheel and the handle.

Sheldon: Oh, it took me forever to get him on a bathroom schedule. He would just go whenever the mood struck him.
Amy: Like a dog boy.
Sheldon: Exactly.

Howard: You're still at my mother's?
Raj: I'm trapped. My clothes have been in the laundry all day, and she hid my keys. I think they might be in her bra, because she jingles when she walks. What do I do?
Howard: Hey, you wanted a woman in your life. Now you got one.

Raj: I've had a lovely time eating your brisket and hearing about the things you've had removed from your body over the years. Didn't know you could have a cyst inside another cyst.
Mrs. Wolowitz: The doctor said they were like Russian nesting dolls.

Leonard: I don't have to put up with this.
Sheldon: Actually, I have your signature on a Roommate Agreement that says you do.
Leonard: Here's what I think of your Roommate Agreement.
Sheldon: You pick that up right now.
Leonard: No.
Sheldon: Roommate Agreement, Section 27, Paragraph 5: "The Roommate Agreement, like the American flag, cannot touch the ground."

Howard: My mom's been kind of an emotional wreck since that dentist she was dating dumped her.
Raj: Dumped her? What, did he use a forklift? Sorry. There's nothing funny about morbid obesity.
Howard: She's huge. It was funny.

Penny: I love him. This is just happening too fast.
Sheldon: You think this is fast? It's just a matter of time before I see Amy's leg stubble in my shower.
Penny: Yeah, and I've seen those legs. You might want to get some Drano.

Leonard: Oh, could you clear off a shelf for me in the bathroom? I take a lot of medicine.
Penny: Oh, please let some of it be Xanax.