Sheldon: No I should apologize. I never realized to what extent our friendship was a burden to you.
Leonard: That is not fair. I complain about what a burden it is at least once a month.
Sheldon: No, no, no. Let's not sugarcoat this. You find me finnicky, pedantic and annoying.
Penny: No, he doesn't.
Leonard: I have actually used those exact words before. In that order.

Howard: I'm definitely up a cup size.
Raj: Yeah, but they're firm. So you've got that going for you.
Howard: Thanks, I needed that today.

Sheldon: Really? The only time I'm ever picked first for a team and I'm stuck with the liability?

Bernadette: Hey, Romeo. Repair your relationship on your own time!

Raj: Okay, let's try it again. But this time, pretend the girl you want to meet doesn't want to hurt you.
Stuart: I don't think I can give you that.

Raj: Attention all shoppers, my business is open for business!

Penny: Bernadette told me everything. Now you don't get the left or the right.

Sheldon: Did you know that Los Angeles has a little Sri Lanka?
Leonard: I did not.
Sheldon: Well, I do now. They're a lovely people, although terrifying when you wake up face to face with them.

Howard: (To Raj) Will you play the ukelele?
Raj: Sure, I'd be happy to shred it on my axe.
Howard: Or you could just play your tiny, ridiculous guitar.

Howard: You sure you're okay?
Bernadette: Yeah, it's just a precaution. If there were a problem I'd be throwing up through my eyeballs by now.

Amy: I've never seen him (Sheldon) this happy before.
Leonard: That's because you've never seen him on "Restock the Medicine Cabinet" day.

Leonard: Dr. Jeffries, hello again. Leonard Hofstadter.
Professor Proton: Oh, right. I remember your girlfriend. *Looking around* Is she here?

Raj: There are just some things I feel more comfortable sharing with the girls. Because they won't make fun of me, or call me names, or ask me if my Koothrapanties are in a bunch.

Professor Proton: (To Penny) So, you have any single grandmothers?
Penny: Sorry, they're both married.
Professor Proton: Good. .... Happily?

Leonard: So when you say you're not going to flip out about the DVD, here's what that means. Don't fixate on it, or wake me up in the middle of the night, or nag me through the door while I'm on the toilet.