Penny: Sheldon?
Sheldon: Mm, absolutely not, no. The Nobel committee will be making the calls to inform the winners at any minute, so the only drug I need is the endorphins pumping through my brain in anticipation of our victory.
Amy: Well, technically, anticipation wouldn't be mediated by endorphins as much as dopamine, but, you know, you've been up all night, so I'll give you that one. [Amy looks and sees Sheldon is asleep] Really? The second he stops talking?

Raj: And we are fortunate to have one of those men here with us tonight. Please welcome to the Griffith Observatory astronaut Howard Joel Wolowitz.
Bernadette: [fanning herself with the program] Kak horosho.
Leonard: What is she ta-
Penny: Don't ask.

Sheldon: Well I'm here to rescue you from the boredom.
Beverly Hofstadter: Not necessary. This is really quite interesting.
Sheldon: But?
Beverly Hofstadter: But nothing.

Leonard: All right, I'll tell you. Uh, [stammers] Kevin Smith was there, and-and, uh, this really tall guy named Kareem.
Penny: Wait-wait, K-Kareem Abdul-Jabbar?
Leonard: I don't know, it was, uh, Kareem something Jabbar. How do you know him
Penny: How do you not know him?
Leonard: Well, I know him now 'cause he was there.

Leonard: Oh, a-and that, uh, the guy that played the werewolf on-on True Blood, he was there.
Penny: Wh-- Joe Manganiello?
Leonard: Uh, yeah.
Penny: From Magic Mike?
Leonard: What's that?
Penny: Okay, okay, did he look like this?
Leonard: He had his clothes on, but, yeah.

Leonard: And this is a high-pulse laser with a BBO crystal. It's pretty cool. It emits photons in discrete bursts.
Beverly Hofstadter: Huh. Very impressive.
Leonard: But?
Beverly Hofstadter: But what, dear?
Leonard: Oh, I don't know. It's just, usually there's a "but" followed by something that makes me feel bad.

Raj: So, Leonard, what are you gonna do while Penny's away?
Leonard: I don't know. Maybe watch a movie with subtitles.
Sheldon: If you're looking for something outside the norm, I have invented a new chess variant where the bishops can also move like knights.
Raj: What do you call that, Bishops Be Crazy?
Sheldon: First of all, it would be "Bishops Are Crazy."
Raj: Not if you're being crazy.
Leonard: Checkmate.

Howard: Doesn't she have her own place? Why don't you guys hang out there?
Stuart: Oh, she has a roommate, and he's kind of creepy. A-And that's coming from me.

Tam: Look, I was in love with Beth, and she made me happy.
Sheldon: Really? Did she let you play with her train set?
Tam: In a manner of speaking.

Sheldon: It's a congratulations text from my meemaw. [phone vibrates] Ooh. Oh, and there's one from my mom. [phone vibrates] And my sister. [phone vibrates] Oh, and my brother. [phone vibrates] And my brother's ex-wife. [phone vibrates] My brother's other ex-wife. Boy, they don't tell you when you win a Nobel it chews up your phone battery.

Sheldon: I will admit the meeting did not go the way I wanted.
Howard: [imitating Shatner] Because you barfed where no man has barfed before?

Leonard: Hey, do you remember what happened at that first Halloween party that you invited me to?
Penny: When I threw up in the pumpkin?
Leonard: More memorable than that.
Penny: Really? That was pretty impressive.
Leonard: We had our first kiss. On this very couch.
Penny: No, no, our first kiss was at your birthday. Remember? I threw you a party, you didn't make it, and I felt bad for you.
Leonard: No, no, it was on Halloween, and you felt bad for me.
Penny: If we're gonna go through every party where I felt bad for you, we're gonna be here awhile.

Amy: You know, these experiments are pretty harmless. There's one where you just put the baby in front of a mirror and you watch them watch themselves.
Raj: That sounds adorable. Let me see.
Sheldon: How come when she talks about experiments on babies, you think it's adorable, but when I do it, everyone gets upset?
Leonard: I think I can speak for all of us. You're just creepy.
Howard: No offense.

Bernadette: How many times has he made fun of Howard for being an engineer? Going to MIT? His magic?
Amy: Sheldon doesn't make fun of his magic.
Bernadette: Well, he should. It's stupid.

Tam: Hello, Sheldon.
Sheldon: Hello Tam. Thank you for coming. I just want you to know that, um, I forgive you.
Tam: I didn't do anything.
Sheldon: And yet, here I am, still being the bigger man.