Bernadette: Please, that doesn't make you his best friend.
Howard: You know, that reporter asked me if I could put him in touch with Amy's best friend.
Bernadette: That's Penny.
Howard: [singsongy:] Doesn't have to be.

Sheldon: Leonard? Um, I have been agonizing over whether or not to say something to you.
Leonard: Aw. Let me help. Don't.

Sheldon: The point is, we can't afford to have this paper leaked before we're ready to publish. That's how you kiss the Nobel Prize good-bye instead of hello as I intend to do.
Amy: I assume you mean metaphorically.
Sheldon: Absolutely not. If the King of Sweden hands me a medal, I intend to smear it with Purell and then kiss it.

Sheldon: I don't think that you should demand to be in charge of a plasma project.
Leonard: Well, big surprise. You can't stand the idea of me succeeding.
Sheldon: No. I'll be honest. New assertive Leonard is going to take some getting used to. But so did cargo pants Leonard, hmm? Who, for the record, I miss. He always had gum.

Amy: Look at what we made.
Sheldon: I know. It really is the best of both of us. It's got my math and your sassy takedown of the fundamental nature of symmetry. It's got my bottomless intellectual curiosity and your petulant refusal to spell "grey" with an "a" like an American.

Amy: Sheldon, do you want to put the tables after each section or in an appendix at the end?
Sheldon: You know what? We wrote this paper together. I think we should decide together that they go in an appendix at the end.
Amy: How about that? There is an "I" in "team.

Howard: Wil! Wil Wheaton!
Raj: Open! Open!
Wil Wheaton: No. No. No. [to Sheldon] Hell no.

Amy: Sheldon, don't listen to her. She doesn't know what she's talking about. She's crazy!
Mrs. Fowler: Hello, Amy.
Amy: Hello, Mother.
Mrs. Fowler: Great news. We-we can come for Thanksgiving this year.

Sheldon: Oh, we should commemorate this one with a selfie. Oh, look at us, two peas in a pod. Oh, speaking of vegetables, how about I start calling you Old Lady Green Beans?

Penny: So you've been using Sheldon as an excuse to get out of seeing your mother?
Amy: I know. I feel terrible. I love my mom but, you know, sometimes-
Penny: Yeah. We-We've met her.

Raj: Guys, I need your help, okay? I'm trying to buy her engagement ring. What do you think of this? Do you think she'll like this one?
Bernadette: Well, it's hard to say, not knowing much about her. Does she have fingers?
Raj: Yes, she has ten fingers and ten toes. Probably. I'll get back to you after I see her in sandals.

Leonard: Hey, guys.
Sheldon: What are you smiling about?
Leonard: What? This is my regular face.
Howard: No, it's not. Y-Your regular face is more like this-
Raj: No, no, i-it's-it's more in the eyebrows, like this.
Leonard: Okay, make your jokes. I'm still in a great mood. [phone ringing] Hey. Wait, what? Why? Oh, come on, but O-Okay, fine.
Sheldon: Huh, Raj was right, it is more in the eyebrows.

Leonard: I love you.
Penny: I love you, too.
Leonard: And you're gonna do great. Just relax, stay out of your head, and try to enjoy it.
Penny: Aw. That reminds me of what I said to you the first time we slept together.
Leonard: I still use it. It's a mantra.

Mrs. Fowler: Why would Amy feel the need to lie to me?
Amy: Well, perhaps because you're her mother and she didn't want to disappoint you.
Mrs. Fowler: Really? Even after she threw you under the bus, you're still gonna defend her.
Amy: Oh, yes. She's my wife and I love her. And if I can forgive her for putting ketchup on her eggs, I can forgive her for this.
Mrs. Fowler: Her father does that, it's disgusting.
Sheldon: Amy's crazy, you are a delight.

Mrs. Fowler: Thank you, Amy. It's so nice of you to have us over for dinner.
Amy: Couldn't think of a single reason not to.
Sheldon: Yeah, and boy, did she try.
Amy: Thank you, honey.
Sheldon: Oh, you're welcome, dear.