Penny: Oh, my God, he won't stop.
Leonard: How does he keep coming up with new ways to be annoying?
Penny: Nobody knows. That's why he's number one.

Penny: Oh, my God, they're coming right towards us.
Bernadette: We got to get out of here.
Penny: Okay. Well, wait, what about Leonard?
Bernadette: He and his tiny bladder can take the bus!

Sheldon: I understand that we are no longer a couple, but I'd like to remind you that we made a baby together.
Amy: What baby?
Sheldon: A precocious, little Internet show known as Fun with Flags.

Sheldon: I don't think I can go back out there.
Penny: That's fine. You know, I hate that your sister and her friends used to torture you. But what I hate even more is, if I was there, I would have tortured you, too.
Sheldon: Based on this pep talk, I'd say you're still doing it.
Penny: My point is, there was a time I never would've been friends with someone like you, and now you are one of my favorite people. So, if what you need is to spend your birthday in a bathroom, I'm happy to do it with you.
Sheldon: Well, everyone will think I'm weird.
Penny: Sweetie, you are weird. Everyone knows you're weird, but they're all still here because they care about you so much.

Howard: I love you. And I'm not just saying that because your breasts are gonna get bigger.

Amy: Whose bra is this?
Sheldon: It's not yours? Oh, my. How embarrassing for both of us.
Amy: It's Penny's.
Sheldon: Hey. You broke up with me, it's none of your business whose naked bosom I'm smushing around like pizza dough.

Raj: I can't believe Sheldon gave this up.
Leonard: I know. We're gonna have so much more fun than him.
Bernadette: No, they're not.
Penny: Knowing them, they will.

Sheldon: Dear Crazy Future Sheldon, you were driven mad by an earworm. Your mind, once your most trusted asset, is now a sack of parrots and monkeys. So I'm going to tell you everything you need to know. Uh, first, music is dangerous. The movie Footloose tried to warn us, but we wouldn't listen.

Sheldon: (3 knocks) Birthday girl! (3 knocks) Birthday girl! (3 knocks) Birthday girl!

Raj: Come on, a medium-sized asteroid is still an interesting discovery.
Sheldon: I suppose it could end up on a collision course with Earth and destroy life as we know it.
Raj: You dream different than me.

Amy: If you don't mind me asking, why did you and your wife split up?
Dave: Oh, you know how it is. We wanted different things. I wanted children, and she wanted a pastry chef named Jean-Philippe.

Moviegoer: Star Trek stinks!
Wil Wheaton: Yeah? Live long and suck it!

Penny: So what package are you thinking?
Leonard: This one comes with music and flowers. Oh, they even stream the whole thing live on the Internet.
Penny: Why would we want that?
Leonard: Because, there's a lot of gorgeous blondes out there who don't believe they can land a short, near-sighted scientist. Let's give them hope.

Amy: That's Sheldon.
Dave: You're kidding! How's my hair?

Raj: My name is Little Orphan Annie. You killed my father. Prepare to die.
Howard: My name is Darth Vader. I am your father. Prepare to die.