Howard: Why does this matter to you so much?
Bernadette: Because I believe in her, and I make people better. It's what I do.
Raj: Against their will?
Bernadette: It's no fun if they want to. That's just called watching.

Howard: Wil! Wil Wheaton!
Raj: Open! Open!
Wil Wheaton: No. No. No. [to Sheldon] Hell no.

Sheldon: I tried to console her, but nothing seemed to work.
Leonard: Okay, when you say you consoled her, what exactly does that mean?
Sheldon: [sighs] I took a walk, I came back, she was still upset, so I came here.
Penny: Well, I don't see what else you could've done.

Leonard: I think I would've been okay if we weren't sitting so close.
Penny: Well, then, why did we sit so close?
Leonard: Sheldon said, "Are these seats good for everyone?" What was I supposed to do, say no, like a maniac?

Bernadette: Remember, I'm leaving you with two babies. I expect to see two babies when I get back, and they better be the same two babies because I'll know.

Sheldon: Also, if you get a chance to sneak into Hall H, last year, I left my neck pillow under my seat. Uh, third row, second from the aisle.
Penny: I'll see what I can do.
Sheldon: Thank you. At least there will be one superhero in San Diego.

Amy: What do you say? We could both use a break. Come on, I'll do it with you.
Sheldon: Okay, but not in the same tank. I already shared a uterus with my twin sister. I don't need to go through that again.

Sheldon: Is that what I would've sounded like?
Leonard: Yeah.
Sheldon: Yikes!

Howard: So, my incredible wife has some exciting news.
Bernadette: Howie, stop. I don't want to brag.
Howard: Oh, okay, sorry.
Bernadette: Really? No one's gonna ask?
Leonard: Sorry. What's your news?
Bernadette: The drug I've been working on for the past five years just got approved by the FDA.
Penny: Wow.
Raj: Oh, congratulations. Was that the decongestant you developed?
Bernadette: No, we had to rebrand that as a solvent for mining equipment.

Leonard: Um, I picked it. You're the one who told me to stop being such a satisficer all the time.
Sheldon: What? I did not. I just pointed out that you were one. It's what I like best about you. Well, that and those little notes you leave in my lunch.
Amy: I leave those!
Sheldon: Well, that's disappointing. I already know that you heart me. Now I don't know if Leonard does.

Sheldon: I will admit the meeting did not go the way I wanted.
Howard: [imitating Shatner] Because you barfed where no man has barfed before?

Bernadette: Oh, don't waste your time. His name is Danny. He works for one of the other drug companies.
Danny: Hey, nothing wrong with checking out the competition.
Bernadette: Aw, we don't see you as competition.
Danny: You should. Our anti-inflammatory is hitting the market this year, too.
Penny: Well, ours has zero drug interaction risk.
Danny: Yeah. So does an Altoid.
Bernadette: Speaking of Altoids, why don't you go get one?

Bernadette: Hey, what you got there?
Howard: Oh. [stammers] Just tossing out this old helmet I don't need. I thought you were at the park.
Bernadette: We were. The kids got sleepy.
Howard: Great story. I need to make a phone call.
Bernadette: Howard, why do you look all guilty? Like when I catch you deleting your browser history?

Bernadette: We have kids, and it's not smart to put us both in danger.
Raj: That's a good point. When I was little, my parents never flew together. We thought it was because they loved us, but it turns out they hated each other.

Amy: So, obviously, I'm really sorry about my outburst. Calling you frauds was unacceptable. I feel terrible about it.
Sheldon: It has caused her a lot of stress. She chewed through her night guard like it was a piece of jerky.