Sheldon: Leonard, I had no idea your siblings were so much more successful than you.
Raj: Yeah, you're like the Jar Jar Binks of the Hofstadter family.
Howard: Oh, meesa think yousa lookin so, so sad.
Leonard: You know, rather than mock me, my friends might realize that this is difficult and try to help me through it.
Raj: Nope, I think mocking you is more fun.
Howard: Next time, don't yousa bring mama to work. Okee-day?

Leonard: Why are you doing this?
Howard: You know the rules. You brought your mom to work, you must suffer.

Howard: So, Dr. Hofstadter, Leonard rarely talks about his incredibly successful brother and sister.
Leonard: Please, don't go there, Howard.
Howard: I understand that unlike Leonard, they're at the top of their respective fields.
Leonard: Boy, you suck.

Sheldon: What a remarkable woman.
Leonard: Yeah, I thought you guys might hit it off.
Sheldon: I envy you your childhood.
Leonard: I hate to tell you, but the only warm memories I have of my childhood are of my Uncle Floyd.
Sheldon: You're clearly misremembering. Your mother is brilliant, analytical, insightful, and I'm betting she never hit you with a Bible because you wouldn't eat your Brussels sprouts.
Leonard: Sheldon, you don't give your mother enough credit. She's warm, she's loving, she doesn't glue electrodes to your head to measure your brain waves while potty training.
Sheldon: You were lucky. When I was a kid, if I wanted an EEG, I had to attach my own electrodes.

Leonard: So, Mother, what's new?
Beverly Hofstadter: You'll have to be more specific.
Leonard: All right. Uh, what's new with you?
Beverly Hofstadter: Oh, well, I've been having some fascinating menopausal symptoms recently.
Leonard: Maybe something less personal.
Beverly Hofstadter: Oh. Your Uncle Floyd died.
Leonard: Oh, my God. What happened?
Beverly Hofstadter: His heart stopped beating. I have to urinate.

Howard: Just for the record, we're not in an ersatz homosexual relationship.
Raj: Well, then why didn't you say that to her?
Howard: Why is it always my responsibility?
Raj: It's not always your responsibility. I swear, this is the same thing you did at the comic book store last week.
Howard: I can't believe you're bringing that up.
Raj: I didn't bring it up. You did.
Howard: We'll talk about this later.
Raj: You always say that, but we never do.

Penny: Wow, you got a lot of money in there.
Sheldon: That's why it's guarded by snakes.

Penny: The building manager's showing an apartment downstairs, and I haven't paid my rent.
Sheldon: Oh, I see. Penny, I'm not sure I'm comfortable harboring a fugitive from the 2311 North Los Robles Corporation.

Leonard: Sheldon, would you be prepared on a non-presidential basis, to create an emergency ad-hoc slurpee/icee equivalency?
Sheldon: Oh Leonard, you know I can't do that.

Leonard: Come on, there's four of us and one of him.
Sheldon: Which means his triumph will be even larger. Minstrels will write songs about him.

Raj: If anyone cares, I still have to pee.

Leonard: OK, is everyone clear on the plan?
Howard: Yes, Koothrappali's going to wet himself, I'm gonna throw up, Sheldon's gonna run away and you're going to die. Shall we synchronize our watches?

Kurt: Where's your back up?
Leonard: I don't need back up, I have right on my side ... and I'm wearing cargo shorts under my pants.

Howard: Maybe we should have your head notarized.

Penny: No, I can't. Sheldon, honey, I don't want things to be weird between us.
Sheldon: Won't it also be 'weird' if I have to say hello to you every morning on my way to work and you're living in a refrigerator box and washing your hair with rainwater?