Leonard: (On the phone) I'm really very busy. Is there any way that we can put this off until I have more time to prepare? ... Of course. But, uh, you understand my trepidation.
Penny: What's that about?
Howard: Not a clue.
Leonard: Can't we just postpone it till the spring? Maybe next summer?
Sheldon: This should be fairly easy to deduce. He's holding the phone to his left ear. Ears do not cross hemispheres, so he's using the analytical rather than the emotional side of the brain, suggesting that he has no personal relationship with the caller.
Leonard: No, I didn't realize it had been so long. Sure, I guess there's no other choice but to just go ahead and do it.
Sheldon: He's referring to an activity he has done before. It's unpleasant and needs to be repeated. This suggests some sort of invasive medical test, like perhaps a colonoscopy.

Penny: I know my dad wanted a boy. I just, I tried being good at sports, but I hated getting dirty!
Beverly Hofstadter: And then, I'm assuming you entered adolescence.
Penny: Uh-huh. He called me Slugger until I got my first training bra, and then he just stopped playing catch with me. I wasn't Slugger anymore. (As Leonard opens the door) Your mother's here!

Leonard: Here's your tea, mother.
Beverly Hofstadter: Oolong?
Leonard: Yes.
Beverly Hofstadter: Loose, not bagged?
Leonard: Yes.
Beverly Hofstadter: Steeped three minutes?
Leonard: Yes.
Beverly Hofstadter: Two-percent milk?
Leonard: Yes.
Beverly Hofstadter: Warmed separately?
Leonard: Yes.
Beverly Hofstadter: One teaspoon sugar?
Leonard: Yes.
Beverly Hofstadter: Raw sugar?
Leonard: Yes.
Beverly Hofstadter: It's cold.
Leonard: I'll start again.

Sheldon: I have the same problem with him. My theory is that his lack of focus stems from an over-developed sex drive.

Leonard: Here's your tea, Mother. So, what are you guys talking about?
Sheldon: The frequency with which your parents had intercourse.
Leonard: Swell. If you're lucky, maybe she'll show you the PowerPoint presentation.

Sheldon: What a remarkable woman.
Leonard: Yeah, I thought you guys might hit it off.
Sheldon: I envy you your childhood.
Leonard: I hate to tell you, but the only warm memories I have of my childhood are of my Uncle Floyd.
Sheldon: You're clearly misremembering. Your mother is brilliant, analytical, insightful, and I'm betting she never hit you with a Bible because you wouldn't eat your Brussels sprouts.
Leonard: Sheldon, you don't give your mother enough credit. She's warm, she's loving, she doesn't glue electrodes to your head to measure your brain waves while potty training.
Sheldon: You were lucky. When I was a kid, if I wanted an EEG, I had to attach my own electrodes.

Howard: So, Dr. Hofstadter, Leonard rarely talks about his incredibly successful brother and sister.
Leonard: Please, don't go there, Howard.
Howard: I understand that unlike Leonard, they're at the top of their respective fields.
Leonard: Boy, you suck.

Leonard: Why are you doing this?
Howard: You know the rules. You brought your mom to work, you must suffer.

Sheldon: Leonard, I had no idea your siblings were so much more successful than you.
Raj: Yeah, you're like the Jar Jar Binks of the Hofstadter family.
Howard: Oh, meesa think yousa lookin so, so sad.
Leonard: You know, rather than mock me, my friends might realize that this is difficult and try to help me through it.
Raj: Nope, I think mocking you is more fun.
Howard: Next time, don't yousa bring mama to work. Okee-day?

Beverly Hofstadter: So, where were we?
Leonard: Howard lives with his mother and Raj cant speak to women unless hes drunk. Go.
Beverly Hofstadter: That's fascinating. Selective mutism is quite rare. On the other hand, an adult Jewish male living with his mother is so common it borders on sociological clich.

Leonard: You brought your husband to work, you know the rules. Meesa thinking yousa looking pretty sad now too, betcha, betcha.

Beverly Hofstadter: Leonard, it's one o'clock, weren't you going to show me your laboratory at one o'clock?
Leonard: There's no hurry, Mother, tell them more about their secret love for each other.
Beverly Hofstadter: But it's one o'clock, you were going to show me your laboratory at one o'clock.
Sheldon: Her reasoning is unassailable. It is one o'clock.

Leonard: I think you'll find my work pretty interesting. I'm attempting to replicate the dark matter signal found in sodium iodide crystals by the Italians.
Beverly Hofstadter: So, no original research?
Leonard: No.
Beverly Hofstadter: Well, what's the point of my seeing it? I could just read the paper the Italians wrote.

Howard: Just for the record, we're not in an ersatz homosexual relationship.
Raj: Well, then why didn't you say that to her?
Howard: Why is it always my responsibility?
Raj: It's not always your responsibility. I swear, this is the same thing you did at the comic book store last week.
Howard: I can't believe you're bringing that up.
Raj: I didn't bring it up. You did.
Howard: We'll talk about this later.
Raj: You always say that, but we never do.

Penny: Hey.
Leonard: You got alcohol?
Penny: Your mom still here?
Leonard: Yep.
Penny: Come on in.