Leonard: Sheldon, I wasn't done talking. She hands in the paper tomorrow. I know I could help her. And she's my girlfriend. I, I should be allowed to help her. Why aren't I allowed to help her?
Sheldon: Yeah, I hear you, brother.
Leonard: No. You need to give me some advice.
Sheldon: Fine. Women, huh?
Leonard: No, specific to my situation.
Sheldon: Blond women, huh?
Leonard: Empathetic.
Sheldon: It sucks to be you.
Leonard: I quit.

Sheldon: What if we were to go as dinner table favourites salt and pepper?
Amy: You know salt makes me retain water and my cousin William was ground to death in a pepper factory accident.

Sheldon: Professor Proton hosted my favorite science show when I was a child. I never missed an episode. He demonstrated scientific principles using everyday objects.
Leonard: It was pretty cool.
Penny: Aw, it's so cute when you use the word cool wrong. Like when kids say pasgetti.

Sheldon: They can't just cancel a show like Alpha, you know. They have to help the viewers let go. Firefly did a movie to wrap things up. Buffy the Vampire Slayer continued on as a comic book. Heroes gradually lowered the quality season by season 'til we were grateful it ended.

Leonard: Hang on. Are you feeling insecure? Because that's my thing, and if you take it away, I don't know what I'm bringing to this relationship.

Bernadette: Sheldon, I've been cooking all day.
Sheldon: Well, now don't you feel silly.
Bernadette: (To Howard) Show him the closet.

Sheldon: Earlier today, I invited Professor Stephen Hawking to join me in the popular online game Words with Friends. Moments ago, he accepted my request. Do you understand what that means?
Howard: That somewhere right now Stephen Hawking is saying, "Damn it, I mean to click no."

Sheldon: I'll walk you through it. This game is not called Words with Strangers. No, it's not even called Words with Acquaintances. It's called Words with-
Raj: I'm not finishing your sentence. You pulled the plug on my funk.
Sheldon: Friends! It's Words with Friends. Which Stephen Hawking and I officially are. Now all I need is a bunk bed with a slide, and I'll have everything I've ever wanted since I was six years old.

Sheldon: I don't see why I'm the one being persecuted here. Dr. Hofstadter, he was bragging about his sexual desirability to anyone who would listen. You know, and Howard Wolowitz, he spent two years using university resources building a six-breasted sex robot. Oh, and at the office Christmas party, I heard Rajesh Koothrappali refer to you several times as Brown Sugar.
Ms. Davis: Hofstadter. Wolowitz. And the last one was Rajesh Koothrappali?
Sheldon: Yes. No, yeah, but in his defense, that wasn't racist. He's also brown.

Howard: Sheldon, I know Stephen Hawking. I worked with him.
Sheldon: And if they ever come out with a game called Words with People You Once Worked With, you'll be off to the races.

Penny: Hey, shouldn't you be out with your gang, spray painting equations on the side of buildings?
Leonard: Come on, I'm sorry.

Amy: Check this out. I took the liberty of scripting a new outgoing voice mail message for both of us.
Sheldon: Hello. This is Sheldon.
Amy: And this is Amy.
Sheldon: We're not home right now.
Amy: 'cause we out dropping science, son.
Both: Leave a message.
Amy: Beep.

Amy: As you know, I had planned a traditional evening of romance and gifts.
Sheldon: Yes, and as you know, I planned to pretend to enjoy it. I've been working on this facial expression all day.
Amy: And I appreciate your effort, but upon contemplation, I decided I was being selfish. So, I canceled our dinner reservations and came up with an even better way to celebrate Valentine's Day.
Sheldon: What is that?
Amy: By doing none of it. No dinner, no romance, no gifts. We stay here, order a pizza and watch one of your beloved Star War Trek things.

Sheldon: This is the most thoughtful gift that anyone's ever given me. And that's including an amazing gift that I gave myself earlier today.

Sheldon: I believe the painful sensation felt after passing a meal of spicy chillies is proof that the rectum does possess the sense of taste.