Beverly Hofstadter: Sheldon, I know the future holds great things for you, and we all can't wait to see what they are. Happy birthday, dear.

Barry Kripke: Someone call Animal Control. There's a cougar on the loose.
Beverly Hofstadter: Barry, stop.
Leonard: Seriously, Barry, stop.

Leslie Winkle: Uh, in the past, I would've said something obnoxious, like, "Happy birthday, dumbass". But I'm not gonna do it. You and I have both grown a lot, and it's just so nice to see you all again. So happy birthday, Sheldon.
Sheldon: Oh. Oh, now, you know I hate change. Say it.
Leslie Winkle: Happy birthday, dumbass!

Adam West: Happy birthday, young man. And if any of you have enjoyed seeing me here today, I'm also available for Comic-Cons, bachelor parties, bar mitzvahs...

Sheldon: Wil Wheaton, go.
Wil Wheaton: Sheldon, I know that we've had our ups and downs, but I can honestly say that my life is so much more interesting because you are in it. We may have met because you are a fan of Star Trek. But I have become a fan of Sheldon Cooper. Live long and prosper, buddy. And happy birthday.
Sheldon: That's how you do it, Wolowitz. Now you see why he's famous and you're not.

Barry Kripke: (Knocking) Hello! Some of us need to check our hair because we might have a shot with Leonard's mother.

Penny: Okay, everybody, Sheldon is gonna come back out, but I think he's a little embarrassed, so let's all be extra nice, okay?
Barry Kripke: What are you looking at me for? I'm a saint. (chuckles) But a sinner in the sack.

Howard: Sheldon, I don't think everyone-
Sheldon: Wolowitz, perfect. Everyone listen to Wolowitz.
Howard: Okay, then, uh, Sheldon, we've known each other a long time. And it is a pleasure to work with you and call you my friend.
Sheldon: Little generic. Keep thinking. We'll circle back.

Leslie Winkle: Leonard. Hey, it's been a while.
Leonard: Leslie. I can't remember the last time we talked. So much has changed.
Leslie Winkle: Has it?
Leonard: Yeah, uh, um, Penny and I got married.
Leslie Winkle: Wow, congratulations. You know, actually, I thought you'd be living with Sheldon forever.
Leonard: Yeah, .... Well, don't be a stranger.

Leonard: Okay, I'd better go in there and talk to him.
Amy: Well, don't you think I'm the one who should go in?
Leonard: No offense, but I've known the guy a really long time.
Amy: Well, I've, you know, seen him without pants on.
Leonard: Again, no offense, but so have I.
Amy: Well, he's seen me without pants on.
Leonard: Again, -
Penny: Okay, this is ridiculous.

Penny: So what's going on?
Sheldon: I don't know. I looked around the room, and I saw all the faces and the presents, and it it was just too much.
Penny: I get that. Hey, you want to just bring a few people in here? You know, Wil Wheaton in the bathtub, Batman on the toilet. It'll be like the weirdest Comic-Con ever.

Penny: Sheldon, can I come in?
Sheldon: How do you know I'm not using the facilities?
Penny: Because you e-mail me your bathroom schedule once a week, even though I've clicked unsubscribe, like, a thousand times.

Sheldon: I know that you worked hard to put this together. I'm sorry I'm ruining it.
Penny: Oh, pl- you're not ruining it. Look, at some point, Raj will try to get everyone to do the Electric Slide. Now, that will ruin it.

Sheldon: I don't think I can go back out there.
Penny: That's fine. You know, I hate that your sister and her friends used to torture you. But what I hate even more is, if I was there, I would have tortured you, too.
Sheldon: Based on this pep talk, I'd say you're still doing it.
Penny: My point is, there was a time I never would've been friends with someone like you, and now you are one of my favorite people. So, if what you need is to spend your birthday in a bathroom, I'm happy to do it with you.
Sheldon: Well, everyone will think I'm weird.
Penny: Sweetie, you are weird. Everyone knows you're weird, but they're all still here because they care about you so much.

(After Sheldon runs out of his party)
Adam West: I still get paid, don't I?