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Quote from Sheldon in the episode The Large Hadron Collision

Sheldon: I've been dreaming about going to the Large Hadron Collider since I was nine years old.
Leonard: Yeah, well, I've been dreaming about spending Valentine's Day with a girl since I was six.
Sheldon: Shame on you! That's no dream for a scientist.

Quote from Penny in the episode The Large Hadron Collision

Leonard: This tray contains clues as to what you and I are going to be doing on Valentine's Day.
Penny: Oh, wow. Okay. Let's see. We've got milk chocolate, Swiss cheese, fondue.
My lactose-intolerant boyfriend is going to eat all this, then I'm going to climb on his back and rocket to the moon?

Quote from Sheldon in the episode The Large Hadron Collision

Leonard: Who's miserable and alone?
Raj: Me.
Leonard: Oh, I used to be like that. Then I got a girlfriend.
Sheldon: In pre-1976 terms, neener-neener.

Quote from Sheldon in the episode The Large Hadron Collision

Leonard: Okay, I know what'll cheer you up, let's play one of your driving games.
Sheldon: All right. This game is called Traitors. I will name three historical figures, you put them in order of the heinousness of their betrayal. Benedict Arnold, Judas, Dr. Leonard Hofstadter.
Leonard: You really think I belong with Benedict Arnold and Judas?
Sheldon: You're right. Judas had the decency to hang himself after what he did.

Quote from Raj in the episode The Excelsior Acquisition

Howard: Ow. Damn, paper cut. Nothing worse than a paper cut.
Raj: Well, obviously you don't remember your circumcision.

Quote from Sheldon in the episode The Excelsior Acquisition

Howard: Sheldon, why do you have all these unopened paychecks in your desk?
Sheldon: Because most of the things I'm planning to buy haven't been invented yet.
Howard: But there must be thousands of dollars here. Why don't you put it in the bank?
Sheldon: I don't trust banks. I believe that when the robots rise up, ATMs will lead the charge.

Quote from Sheldon in the episode The Excelsior Acquisition

Sheldon: Ill tell you where I've been. You boys may have had gelato with Stan Lee and gotten autographed comics, but I saw the inside of his house and got an autographed application for a restraining order.
Howard: Sweet.
Sheldon: Plus, I get to hang out with him again at the hearing. This is going to look great hanging next to my restraining order from Leonard Nimoy.

Quote from Sheldon in the episode The Staircase Implementation

Sheldon: And next, if either of us ever invents time travel, we agree our first stop will be this meeting today in precisely five seconds.
Leonard: Okay. [They look around, nothing happens]
Sheldon: Well that's disappointing.

Quote from Raj in the episode The Plimpton Stimulation

Raj: Go away. She wants New Delhi, not Kosher deli.

Quote from Sheldon in the episode The Plimpton Stimulation

*Raj sneezes*
Sheldon: Hold.
Raj: What?
Sheldon: Explain your sneeze.
Raj: I'm sorry?
Sheldon: Do you have allergies?
Raj: No.
Sheldon: Is there too much pepper on your salad?
Raj: I don't put pepper on salads.
Sheldon: I've heard enough. Sit over there.

Quote from Sheldon in the episode The Plimpton Stimulation

Sheldon: Vocal test. Morning vocal test. Second vocal test. Second morning vocal test.

Quote from Sheldon in the episode The Jiminy Conjecture

Penny: You may be right about me and Leonard.
Sheldon: Of course I'm right What are the odds I'd be wrong twice in one week?
Penny: No, I mean, we can always go back to being friends.
Sheldon: I just said that. This conversation has started to circle. Meeting adjourned.

Quote from Sheldon in the episode The Staircase Implementation

Leonard: You know what, go to Hell and set their thermostat.
Sheldon: I don't have to go to Hell. At 73 degrees, I'm already there.

Quote from Penny in the episode The Adhesive Duck Deficiency

Penny: Sing Soft Kitty to me.
Sheldon: Soft Kitty is for when you’re sick. You're not sick.
Penny: Injured and drugged is a kind of sick.
Sheldon: [sings] Soft kitty, warm kitty, little ball of fur…
Penny: Wait, wait. Let's sing it as a round. I'll start. [sings] Soft kitty, warm kitty, little ball of fur… See that's where you come in. I'll start over. [sings] Soft kitty, warm kitty, little ball of fur… I've got all night, Sheldon. Soft kitty, warm kitty…
Both: [sing] ...little ball of fur, happy kitty, sleepy kitty, purr, purr, purr.

Quote from other character in the episode The Jiminy Conjecture

Crawley: Ha-ha. Don't knock, just walk in. Why be polite to the world's leading expert on the dung beetle?

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