Howard: Look, if you don't want to go to the party, just don't go. You're a grown man. Act like one. Tell Amy you want to spend the weekend having a sleepover and playing video games with your friends!

Raj: No, I'm not gay. If anything, I'm metrosexual.
Dr. Koothrappali: What's that?
Raj: It means that I like women, as well as their skin-care products.

Penny: Strap on a pair and go talk to Amy.
Sheldon: Strap on a pair of what? ...Skates?
Penny: Oh, you are so not the guy.

Sheldon: If it's good enough for Kirk, Crunch, and Kangaroo it's good enough for me.

Penny: Really? On top of everything, you're afraid of birds?
Sheldon: Its called ornithophobia and someday it will be recognized as a true disability, and the landlord will be required by law to put a giant net over the building. Which is unfortunate because I have a fear of nets.

Bernadette: Oh, I don't know. I don't want to manipulate him with sex.
Penny: Oh, sweetie, that's what sex is for.

Raj: (Talking to the snake) Let's go to the biology lab and find you some nice yummy mice.
Sheldon: I tried to scare an Indian with a snake. Come on, Cooper. You're better than this.

Sheldon: New topic: women. Delightfully mysterious or bat-crap crazy?

Amy: Goodnight, Stuart.
Stuart: Goodnight.
*Stuart and Amy hug*
Sheldon: (From inside Amy's apartment) Take the hint, Stuart, the lady said goodnight!

Sheldon: Would you like some aloe vera? 'cause you just got burned.

Sheldon: I know he (Spock) wouldn't care for an outburst of human emotion, but oh goodie, oh goodie, oh goodie!

Sheldon: I'm trying to raise the temperature in here before my nipples tear through my shirt.

Sheldon: The two of you need to get your women in line!
Leonard: What?
Sheldon: Last night, I was strong armed into an evening of harp music and spooning with an emotional Amy Farrah Fowler. This on a night that I had originally designated for solving the space time geometry in higher spin gravity and building my Lego death star. And why? Because your gal pals, Penny and Bernadette, went out shopping for some wedding nonsense without Amy. An action they took with no thought or regard as to how it would affect me, the future of string theory, or my Lego fun time!
Howard: What do you want us to do about it?
Sheldon: You clearly weren't listening to my topic sentence. Get your women in line! You make them apologize to Amy and set things right. I am a man of science, not someone's snuggle bunny!
Leonard: Why do I have to talk to Penny? She's not my girlfriend.
Sheldon: You invited her to lunch four years ago. Everything about her is on you. You make it so!

Sheldon: And now that I have some wood, I'm going to begin the erection of my settlement.

Bernadette: It would mean so much if you would be the maid of honor at my wedding.
Amy: What? Wait is this some kind of practical joke? Like in Norway when my "friends" trapped me in a sauna with a horny otter?