Sheldon: Some people are otters, some people are rocks.

Amy: It's fine. I'm used to being the girl who never gets looked at twice. I didn't have my first kiss until I was 22. And the guy only did it so I'd give him back his insulin.
Bernadette: Sometimes the pancreas wants what the pancreas wants.

Amy: Sheldon told me he had a new assistant named Alex. He didn't mention that Alex was a girl.
Penny: Maybe he didn't notice.

Sheldon: Leonard, come back. Leonard, come back. Leonard, come back.
Leonard: What?
Sheldon: Oh, of course, it only works on the weak-minded.

Sheldon: Amy's taking me to a memorial service. It's for one of her colleagues who is of Asian descent, so my planned conversational gambit is to casually remark that no matter how deep they dig his grave, he'll never make his way back to China.
Leonard: That should lighten the mood.
Sheldon: What can I say? I put the fun in the funeral.

Bernadette: How you doing, Howie? You feeling a little better?
Howard: Oh, a lot better, thanks. One sec. Listen close, I don't have a lot of time. I need you to go to my house. In my bedroom, you'll find a model rocket. I want you to take it and bring it back to your place.
Bernadette: Okay.
Howard: Step two, build a version roughly fourteen stories high. Fill it full of rocket fuel and come get me. I'll leave the door unlocked.
Bernadette: Howie, honey, maybe you should talk to someone, let them know you're having a little anxiety.
Howard: No, no, I'm fine. No anxiety. We should probably talk in code. From now on, frog is me, sandwich means you and lemon means rocket. So, come on, sandwich, build me a lemon 'cause froggy wants to come home.

Penny: Well, of course he's desirable. I mean, he's great. He's smart, he's sweet and, ooh, in the bedroom, whew, let me tell you he really tries.

Penny: Okay, glasses off. Find Waldo.

Bernadette: You know, one of the things that helped me get through Howard being in space for so long was getting married before he left.
Penny: Bernadette, sweetie, shut up.

Sheldon: Now, Penny, we don't consume alcohol during Dungeons and Dragons. It impairs our judgment.
Penny: Oh, this isn't alcohol. It's a magic potion that makes me like you.
Leonard: Double potion, please.

Amy: What if you could find a roommate who was a scientist and already familiar and comfortable with your ways.
Sheldon: That would be ideal. If a person like that existed, I would sign on, no further questions asked.
Amy: Great. Here I am!
Sheldon: Wait. Here who is where?
Amy: Me. Aren't I your perfect roommate?
Sheldon: Um...
Amy: Think about it, Sheldon. I'm not a stranger, we're both intellectually compatible, I'm willing to chauffeur you around town, and your personality quirks, which others find abhorrent and rage-inducing, I find cute as a button. What do you think?
Sheldon: Um.
Amy: Tell me one reason why this isn't a fantastic idea.
Sheldon: Um.
Amy: See? You can't. I'm gonna go see if Leonard's room is big enough for my water bed.
Sheldon: Um.

Bernadette: More coffee?
Penny: No, Leonard's taking me to a physics lecture, and coffee'll just keep me awake.

Howard: People change names on blogs to protect their privacy. Roger is Raj.
Raj: Oh, I always thought if I had a white name it would be Gavin.

Leonard: Where have you been?
Sheldon: Oh, Leonard, if I was prone to sarcasm I'd say I was pulling off a major heist at the museum of laundry baskets.
Leonard: (Counts to 10 and takes a breath) What I meant was, gee Sheldon! You were gone a long time!

Sheldon: I found three bowling pins. Do you juggle these or are you missing seven?
Howard: Juggle.
Sheldon: You health nuts kill me.