Penny: What up, Shel-bot?

Sheldon: What I am doing here is trying to determine when I am going to die.
Leonard: A lot of people are working on that research.

Sheldon: I believe I may have cholera.
Leonard: There's no cholera in Pasadena. Just like last summer when there was no malaria in Pasadena.

Sheldon: An entire dinner to talk about your research? Where you going? The drive thru at Jack In The Box?

Sheldon: Why hast thou forsaken me, O deity whose existence I doubt?

Sheldon: I've never said these words before, but good job, Howard.

Sheldon: (Waving Zork game) Pick me, pick me, I'm fun.
Kripke: That all sucks the big hairy meatball.

Sheldon: This is where we could've been if we hadn't stopped for dinner. This is where we could've been if Koothrapali hadn't ordered dessert.
Raj: I earned it, I ate all my brocolli.

Sheldon: I'm not saying that all senior citizens that can't master technology should be publicly flogged. But, if we made an example of one or two it might give the others incentive to try harder.

Sheldon: And what a civilisation is the Greeks. They gave us science, democracy and little cubes of charred meat that taste like sweat.

Sheldon: Oh! There isn't enough chamomile tea in the world to quell the rage in my heart.

Sheldon: Perhaps your talk of my sexual prowess renewed her faith in love.

Amy: We need to fabricate a tantalising piece of gossip.
Sheldon: And a second non-tantalising piece to use as a control.
Amy: Then we'll track its progress through our social group and interpret the results through the competing academic prisms of mimetic theory, algebraic gossip and epidemiology.
Sheldon: Look at you, getting me to engage in the Social Sciences. You're a vixen, Amy Farrah Fowler.

Sheldon: Leonard, the people at Nintendo can only go so far in helping us recreate an actual athletic experience. We have to do our part too.

Leonard: The robot hand got stuck on your what?