Sheldon: Amy, when I look in your eyes and you're looking back in mine, everything feels not quite normal. Because I feel stronger and weaker at the same time. I feel excited and, at the same time, terrified. The truth is, I don't know what I feel, except I know what kind of man I want to be.
Amy: Sheldon, that was beautiful.
Sheldon: I should hope so, that's from the first Spider-Man movie.
Amy: I'll take it.

Stuart: Hey. Hey, look at you guys!
Amy: I'm Raggedy Ann, and he's Raggedy C-3PO.
Sheldon: It was a compromise. I lost.

Amy: We could go to the cadaver lab at UCLA and play real-life Operation.
Leonard: Uh-uh.
Sheldon: No.
Penny: I don't think so.
Amy: Are you sure? I mean, the nose doesn't light up, but if the corpse is fresh enough, sometimes you can get the leg to jerk.

Sheldon: She's remarkable.
Leonard: She really is.
Sheldon: How is it that she can remember all those lines, yet as a waitress she can't remember no tomato on my hamburger?

Sheldon: You know, its a tad old-school, but my father was not one to spare the rod when my brother would sneak into his truck and drink his driving whiskey.
Amy: You want to spank me?

Penny: You're unbelievable.
Sheldon: I know.

Sheldon: Well, that's a fine how-do-you-do. (To Amy) Don't just stand there. Take your breasts out.

Howard: A week ago, I was an astronaut.
Bernadette: Yeah, well, today you're a Smurf! Keep moving!

Sheldon: Yeah, you had a good run, fake Wolowitz. We'll remember you with nostalgic fondness. The way we do the dial-up modem, the VHS tape, or Leonard's gym membership.

Sheldon: You know what they say. Revenge is a dish best served nude.

Stephen Hawking: What does Sheldon Cooper and a black hole have in common? They both suck.

Sheldon: The word is Polish. See, look.
Polish sausage. And the model of the solar system developed by Nicolaus Copernicus, a Polish astronomer. And then, finally, if that wasn't enough, which it should've been, this is Madame Curie killing herself by discovering radium, who, although she was a naturalized French citizen, was Polish by birth.
Penny: Excuse me, the word is polish. See? Small p.
Sheldon: Ah! So it is. I guess we both share blame on this one.

Sheldon: Leonard, make Howard stop being naked in my spot!

Penny: You know, I remember my first bikini wax. My sister did it with duct tape and melted Crayolas. To this day, I can't look at a box of crayons without crossing my legs.

Raj: Insurance will replace your car, it won't defunk my junk.