Leonard: I'm going to guess that your main concern is the time commitment of watching an entire season of a new show.
Sheldon: Oh, no, not just a season. If I'm in, I'm in for the whole run, even if the quality declines.
Leonard: I get it. Smallville almost wrecked you.
Sheldon: Exactly. You know, I waited ten years to see a guy everyone knows can fly, fly.

Leonard: Was that a flask?
Sheldon: Yes. I've decided to embrace all the traditions associated with prom, including spiking the punch.
Leonard: You're gonna put alcohol in the punch?
Sheldon: Oh, no, this is pomegranate juice. It's all the fun of high-school hijinks, with the self-protecting zip of anti-oxidants.

Howard: Hey guys. I just want everyone to know tonight's not a sad occasion.
Bernadette: Yeah, we just want to have the kind of dinner that we've all had here so many times before.
Howard: Good food. Good friends. And, sometime around midnight, heartburn that makes you pray for death.

Bernadette: If this doesn't get him in to your bedroom, nothing will.

Howard: Raj's parents probably split up because of Raj.
Bernadette: What?
Howard: You always say the children aren't to blame, but (holds up a Raj coaster; chuckles) come on!

Sheldon: I was not panicked, and I am not overly attached to Leonard.
Leonard: You were so worried that you smashed your face trying to check on me. You looove me.

Penny: Oh, I'm just doing this awful work out. I hate it.
Sheldon: Well if you hate it, then why are you doing it? Although I could ask the same question about the coitus with Leonard.

Sheldon: Here at Fun with Flags we've had an opportunity to learn, laugh, wonder.
Amy: And, yes, even shed a tear or two.
Sheldon: Like when you do a two-hour Fourth of July spectacular and it doesn't even get recorded.
Amy: How many times do I have to say I'm sorry?
Sheldon: How about four thousand? One for every domino I set up for that American Flag.

Bernadette: It just builds character. Like my dad said, "Nobody likes a cry baby but their moms and Democrats."

LeVar Burton: Thank you, Sheldon, now remember our deal.
Sheldon: You do this, I delete your contact information.
LeVar Burton: While...?
Sheldon: While you watch me do it.

Sheldon: And if I may get serious for a moment. Hosting this show has been one crazy ride. With all its up and downs, I wouldn't give it up for the world. Except for now, when I'm giving it up.

Bernadette: I thought everybody liked me, but I'm just a monster.
Dan: But a cute one. Like that eyeball guy in Monsters Inc.

Penny: So, how many people listen?
Wil Wheaton: Most people download it later, but usually a few thousand people listen live.
Penny: What? A few thousand people listen to you talk about nerd stuff?
Wil Wheaton: Again, right in the ears, straight to the feelings.

Dr. Koothrappali: Relax? Easy for you to say. Your mother isn't cleaning out your bank account. Forty years, the woman never cleaned a thing.

Leonard: I thought this was gonna be boring but it's actually kinda fun.
Penny: Don't tell Amy that; we'll be here every Sunday.