Amy: Do you think it's possible you might enjoy being on your own for a little while?
Sheldon: It's hard to say. I've never really lived by myself. What if I become strange and eccentric?
Amy: I'll love you no matter what.
Sheldon: Howard Hughes saved his urine in milk bottles.
Amy: We'll cross that bridge when we come to it.

Raj: Well, I can't eat like a ten-year-old all the time.
Penny: You're dating somebody! Who is it?
Raj: What? What are you talking about?
Penny: You only watch what you eat when you're afraid you might have to take your shirt off.

Raj: What's the worst that could come of this meeting?
Howard: I don't know. They take the invention away, and I get nothing?
Raj: Okay, that's not so bad. You know what happened to the scientists that worked on the Manhattan Project? The government forced them to move to the desert. They had to live in secret, and when Oppenheimer objected to what they made him do, they destroyed his reputation.
Howard: What's the point of that story?
Raj: I just read a book about Oppenheimer, seemed like a chance to show off.

Raj: Maybe there are other things we have in common. Come dinner-time, do you enjoy eating food?

Sheldon: You know, I just learned Amy went to a theme park without me, but I'm not going to ruin her birthday. I'll wait, and ruin 24 individual hours sprinkled throughout the year.

Sheldon: Amy is free. She had a harp lesson on Saturday, but it got canceled. Boy, when you take an interest in people, you really uncork a geyser of nonsense.

Howard: The kid with the two shirts screwed us again.

Penny: The new neighbors are weird.

Leonard: Sheldon, this is not a big deal. It's a little white lie, everyone does it.
Raj: Not me, I'm a 100% honest in all of my relationships.
Howard: And how single are you right now?
Raj: Eating-cake-on-the-toilet single.

Bernadette: I now pronounce you husband and wife. And weird other husband who came with the apartment.

Penny: You want food?
Bernadette: Yeah, breastfeeding burns, like, 5,000 calories a day. (To Amy) Do not touch that phone!

Howard: You know, maybe before our meeting we should talk to a lawyer.
Leonard: That's not a bad idea.
Raj: Well, you must have someone in your family that's a lawyer.
Howard: Why? Because I'm Jewish? That's like me saying, "Hey, you're Indian. Doesn't your cousin work in a call center?"
Raj: My cousin does work in a call center.
Howard: And my cousin's a lawyer.

Penny: You know, when Leonard's feeling anxious, I make him take a long walk.
Amy: Does that help?
Penny: For a while, then he comes back.

Sheldon: I admire you, Leonard.
Leonard: Really, why?
Sheldon: You're happy with who you are. You don't get jealous of other people. Instead of being weighed down by ambition, you just float along like a dead body in a river.
Leonard: I couldn't just take the compliment. I had to ask why.

Amy: Sheldon, your mother's an attractive woman. You need to get used to the fact that men are going to be interest in her.
Sheldon: Well, and you need to drive the car and mind your business.
Amy: I will not have you be disrespectful to me.
Sheldon: What- you're not my mother.
Mary Cooper: Don't you be disrespectful to her.
Sheldon: Yes ma'am.
Mary Cooper: You'll get there. You've just gotta put some zing on it.