Howard: Hell hound.
Raj: Who let the satanic dogs out?

Zack: You know, I saw this great thing on the Discovery Channel. Turns out if you kill a starfish it'll just come back to life.
Sheldon: Was the starfish wearing boxer shorts? Because you might have been watching Nickelodeon.

Sheldon: I'd like to go over some proposed changes to the roommate agreement, specifically to address Penny's annoying personal habits.
Penny: Oh my God! What personal habits?
Sheldon: I have a list. FYI overuse of the phrase "Oh my God" is number 12.

Howard: On the potty, what are you five?
Raj: It's a potty, what do you call it?
Howard: A toilet.
Raj: That's a little vulgar for the dinner table, don't you think?
Howard: And potty is okay?
Raj: Potty is innocent. Potty is adorable.
Howard: What do you do on the potty, wee-wee?
Raj: If I don't have to boom-boom.

Leonard: Sometimes your movements are so lifelike I forget you are not a real boy.

Sheldon: At my age, do you know how I'm statistically most likely to die?
Leonard: At the hands of your room mate?
Sheldon: An accident.
Leonard: That's how I'm going to make it look.

Penny: Give my friend his stuff back.
Tod Zarnecki: I don't know what you're talking about.
Penny: Well then good news. Today's the day a girl's finally going to touch you in your little special place. *Kicks him in the groin*

Sheldon: Oh, what fresh hell is this?
Biosuit Nurse: Wait, you can't leave here, you've been exposed.
Sheldon: (Covering his face with his shirt) No, I haven't. It's all good.

Howard: What, I'm not hot enough for Angelina Jolie?
Raj: Id like to weigh in here: No.

Rajesh: Why so glum, chum?
Sheldon: Apparently you can't hack into a government supercomputer and then try to buy uranium without the Department of Homeland Security tattling to your mother.

Raj: Dance number aside, I'm so not gay.

Raj: Sheldon, that's my water.
Sheldon: Oh, dear Lord!
Leonard: That's not your water.
Raj: I know.

Bernadette: Besides, Penny and I are having a girl's night tonight.
Amy: Girls night, what does that entail?
Bernadette: Oh you know, girls get together hang out share girl talk.
Amy: I'm a girl.
Bernadette: Oh well maybe you could join us. I'll ask Penny.
Amy: No need, Penny and I are very close.
Leonard: You are?
Amy: Yes, In fact our mensies are synchronized.

Sheldon: I am aware of the way humans usually reproduce which is messy, unsanitary and based on living next to you for three years, involves loud and unnecessary appeals to a deity.
Penny: Oh, God.
Sheldon: Yes, exactly.

Penny: You wanna turn yourself into some sort of robot?
Sheldon: Essentially, yes.
Penny: Okay, here's my question: Didn't you already do that?